Evidence map›Paper›PMID 35235424›Full record

ArticleAmerican journal of physiology. Cell physiology2022

miR-195 regulates intestinal epithelial restitution after wounding by altering actin-related protein-2 translation.

Shelley R Wang, Navneeta Rathor, Min S Kwon, Lan Xiao, Hee Kyoung Chung, Douglas J Turner, Jian-Ying Wang, Jaladanki N Rao

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  4. Posttranscriptional Regulation of Intestinal Mucosal Growth and Adaptation by Noncoding RNAs in Critical Surgical Disorders.Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2024
    Review
  5. Review
  6. Stabilization ofAmerican journal of physiology. Gastrointestinal and liver physiology · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shelley R WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Navneeta RathorCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Min S KwonCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Lan XiaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Hee Kyoung ChungCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Douglas J TurnerCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Jian-Ying WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Jaladanki N RaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.ORCID 0000-0002-5669-8992
University of Maryland, Baltimore · US

Funding

Intestinal Mucosal Growth in Health & Surgical DiseasesR01DK057819 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2000 to 2026
$7.4M
Surgical Studies of Gut PermeabilityR01DK068491 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2004 to 2026
$7.0M
Mucosal Repair in Gut Surgical DisordersR01DK061972 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, JIAN-YING · 2002 to 2023
$6.7M
REGULATION OF INTESTINAL EPITHELIAL RESTITUTIONI01BX000332 · VA · BALTIMORE VA MEDICAL CENTER · PI Jian-Ying Wang · 2009 to 2026
–
SURGICAL STUDIES ON MUCOSAL HOMEOSTASISI01BX000713 · VA · BALTIMORE VA MEDICAL CENTER · PI WANG, JIAN-YING · 2011 to 2024
–
BLRD Research Career Scientist Award ApplicationIK6BX004213 · VA · BALTIMORE VA MEDICAL CENTER · PI WANG, JIAN-YING · 2018 to 2025
–
BLRD VA I01 BX000332BLRD VA I01 BX000713BLRD VA IK6 BX004213NIDDK NIH HHS R01 DK057819NIDDK NIH HHS R01 DK061972NIDDK NIH HHS R01 DK068491
6 · The paper itself

Abstract

Early gut epithelial restitution reseals superficial wounds after acute injury, but the exact mechanism underlying this rapid mucosal repair remains largely unknown. MicroRNA-195 (miR-195) is highly expressed in the gut epithelium and involved in many aspects of mucosal pathobiology. Actin-related proteins (ARPs) are key components essential for stimulation of actin polymerization and regulate cell motility. Here, we reported that miR-195 modulates early intestinal epithelial restitution by altering ARP-2 expression at the translation level. miR-195 directly interacted with the

Indexed as

Intestinal MucosaMicroRNAsActin-Related Protein 2ActinsCell MovementEpithelial CellsPolyaminesRNA, MessengerWound HealingActin-Related Protein 2ActinsMicroRNAsPolyaminesRNA, Messengeractin-related proteins (ARPs)gut epithelial restitutionmicroRNAsmucosal injurypolyamines

Identifiers

PMID35235424
PMCPMC8977142
OpenAlexW4214828182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.