ArticleAngewandte Chemie (International ed. in English)2022
Self-Regulating Colloidal Co-Assemblies That Accelerate Their Own Destruction via Chemo-Structural Feedback.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Metal-organic framework-based fuel-driven chemical reaction network for ferroptosis therapy.Journal of nanobiotechnology · 2026Article
- Supramolecular Assemblies of Self-Immolative Janus Dendrimers With Rapid Photodegradation Response.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Nature-Inspired Enzymatic Cascades: Emerging Strategies for Sustainable Chemistry.Molecules (Basel, Switzerland) · 2026Review
- Photoactivated Enzymatic Reaction Network Enables Spatiotemporal Programming of Thiol/Disulfide Redox Systems.Angewandte Chemie (International ed. in English) · 2025Article
- Transient colloidal crystals fueled by electrochemical reaction products.Nature communications · 2025Article
- Using a biocatalyzed reaction cycle for transient and pH-dependent host-guest supramolecular hydrogels.Journal of materials chemistry. B · 2024Article
- Transient co-assemblies of micron-scale colloids regulated by ATP-fueled reaction networks.Chemical science · 2023Article
- Article
- Nonlinear Transient Permeability in pH-Responsive Bicontinuous Nanospheres.Journal of the American Chemical Society · 2023Article
- Self-Regulating Colloidal Co-Assemblies That Accelerate Their Own Destruction via Chemo-Structural Feedback.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Biological self-assemblies self- and cross-regulate each other via chemical reaction networks (CRNs) and feedback. Although artificial transient self-assemblies have been realized via activation/deactivation CRNs, the transient structures themselves do mostly not engage in the CRN. We introduce a rational design approach for chemo-structural feedback, and present a transient colloidal co-assembly system, where the formed co-assemblies accelerate their destruction autonomously. We achieve this by immobilizing enzymes of a deactivating acid-producing enzymatic cascade on pH-switchable microgels that can form co-assemblies at high pH. Since the enzyme partners are immobilized on individual microgels, the co-assembled state brings them close enough for enhanced acid generation. The amplified deactivator production (acid) leads to an almost two-fold reduction in the lifetime of the transiently formed pH-state. Our study thus introduces versatile mechanisms for chemo-structural feedback.
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