Evidence map›Paper›PMID 35235185›Full record

SynthesisJournal of nephrology2022

Salivary changes in chronic kidney disease and in patients undergoing hemodialysis: a systematic review and meta-analysis.

Renata Prata Cunha Bernardes Rodrigues, Maria Tereza Campos Vidigal, Walbert A Vieira, Gustavo G Nascimento, Robinson Sabino-Silva, Cauane Blumenberg, Michelle F Siqueira, Walter L Siqueira, Luiz Renato Paranhos

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A Visual Metaphor for Oral Health Education in Hemodialysis Patients: A Pilot Study.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Trial
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  5. Review
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  8. Observational
  9. Article
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  12. Article
  13. Article
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  16. Article
  17. [Latest Research Findings on Health Management Based on Saliva Testing].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Renata Prata Cunha Bernardes RodriguesDivision of Preventive and Community Dentistry, School of Dentistry, Federal University of Uberlândia, Campus Umuarama, Av. Pará, 1720, Bloco 2G, sala 1, Uberlândia, Minas Gerais, 38405-320, Brazil.
Maria Tereza Campos VidigalSchool of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Walbert A VieiraEndodontics Division, Department of Restorative Dentistry, School of Dentistry of Piracicaba, State University of Campinas, UNICAMP, Piracicaba, Brazil.
Gustavo G NascimentoSection for Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Robinson Sabino-SilvaInnovation Center in Salivary Diagnostics and Nanotheranostics, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil.
Cauane BlumenbergDepartment of Social Medicine, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Michelle F SiqueiraCollege of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada.
Walter L SiqueiraCollege of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada.
Luiz Renato ParanhosDivision of Preventive and Community Dentistry, School of Dentistry, Federal University of Uberlândia, Campus Umuarama, Av. Pará, 1720, Bloco 2G, sala 1, Uberlândia, Minas Gerais, 38405-320, Brazil. paranhos.lrp@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study is aimed at describing changes in salivary flow rate and ionic composition present in the saliva of chronic kidney disease (CKD) patients by assessing the pH, calcium, phosphate, and phosphorus concentrations and comparing them to healthy individuals, along with exploring the influence of hemodialysis on these parameters.

methodsThe bibliographical search was performed in nine databases to find all types of studies, including observational clinical studies, without restrictions regarding publication year or language. Two reviewers selected the studies, extracted the data, and assessed the risk of bias using JBI tools. Random-effect meta-analysis was performed with the standardized mean difference (SMD) as effect estimate, at a 95% confidence interval.

resultsThirty-three studies were included in the qualitative synthesis and 31 studies were included in the meta-analysis. Chronic kidney disease patients presented lower salivary flow rate (SMD: - 1.73; 95% CI = - 2.14; - 1.31), higher pH (SMD: 1.57; 95% CI = 1.11; 2.03), and higher phosphorus concentration (SMD: 0.86; 95% CI = 0.63; 1.09) in saliva. Concurrently, salivary flow rate and pH presented significant changes after hemodialysis, with higher salivary flow rate (SMD: 0.53; 95% CI = 0.25; 0.81) and lower pH (SMD: - 0.53; 95% CI = - 0.88; - 0.19) in patients on hemodialysis treatment.

conclusionChronic kidney disease patients present reduced salivary flow rate and increased pH and phosphorus concentration in saliva. Hemodialysis can increase the salivary flow rate of these patients.

Indexed as

Renal DialysisRenal Insufficiency, ChronicCalciumHumansPhosphatesPhosphorusCalciumPhosphatesPhosphorusChronic kidney diseaseSalivaSalivary compositionSalivary flow rate

Identifiers

PMID35235185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.