ReviewHistochemistry and cell biology2022
Optical tissue clearing associated with 3D imaging: application in preclinical and clinical studies.
Review in Histochemistry and cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Modular Platform for Rapidly Investigating Long-Distance Propagation of Human Neural Network Activity.Advanced healthcare materials · 2026Article
- Integrated light and electron microscopy workflow for morphological, molecular and ultrastructural analysis of spheroids.PloS one · 2026Article
- 3D visualization of neurovascular networks in pulp-exposed rat molars using tissue clearing techniques.Odontology · 2025Article
- A novel protein-preserving passive tissue clearing approach using sodium cholate and urea for whole-organ imaging.Experimental & molecular medicine · 2025Article
- Article
- High-Speed Clearing and High-Resolution Staining for Analysis of Various Markers for Neurons and Vessels.Tissue engineering and regenerative medicine · 2024Article
- Cost-effective optimized method to process 3D tumoral spheroids in microwell arrays for immunohistochemistry analysis.Journal of medicine and life · 2024Article
- Characterization Methods for Nanoparticle-Skin Interactions: An Overview.Life (Basel, Switzerland) · 2024Review
- Beyond 2D: A scalable and highly sensitive method for a comprehensive 3D analysis of kidney biopsy tissue.PNAS nexus · 2024Article
- Three-dimensional structural and metric characterisation of cardioids.Frontiers in cell and developmental biology · 2024Article
- ProDiVis: a method to normalize fluorescence signal localization in 3D specimens.Frontiers in cell and developmental biology · 2024Article
- Combining tissue clearing and Fluoro-Jade C labeling for neurotoxicity assessments.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Optical imaging of the small intestine immune compartment across scales.Communications biology · 2023Article
- Long Preservation of AAV-Transduced Fluorescence by a Modified Organic Solvent-Based Clearing Method.International journal of molecular sciences · 2022Article
- In focus in HCB.Histochemistry and cell biology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the inner morphology of intact tissues is one of the most competitive challenges in modern biology. Since the beginning of the twentieth century, optical tissue clearing (OTC) has provided solutions for volumetric imaging, allowing the microscopic visualization of thick sections of tissue, organoids, up to whole organs and organisms (for example, mouse or rat). Recently, tissue clearing has also been introduced in clinical settings to achieve a more accurate diagnosis with the support of 3D imaging. This review aims to give an overview of the most recent developments in OTC and 3D imaging and to illustrate their role in the field of medical diagnosis, with a specific focus on clinical applications.
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