Evidence map›Paper›PMID 35235037›Full record

ReviewJournal of gastroenterology2022

A review on the current status and definitions of activity indices in inflammatory bowel disease: how to use indices for precise evaluation.

Masahiro Kishi, Fumihito Hirai, Noritaka Takatsu, Takashi Hisabe, Yasumichi Takada, Tsuyoshi Beppu, Ken Takeuchi, Makoto Naganuma, Kazuo Ohtsuka, Kenji Watanabe and 13 more

Abstract readReview
In one paragraph

Review in Journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Trial
  2. Practical guidelines on medical management of adults with moderate-to-severe inflammatory bowel disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026
    Article
  3. Article
  4. Article
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  9. Review
  10. Article
  11. Article
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  13. Article
  14. Review
  15. Prospective Questionnaire Survey on Adherence to Oral 5-Aminosalicylic Acid in Patients With Ulcerative Colitis.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Article
  16. Article
  17. Article
  18. Influence of biological sex in inflammatory bowel diseases.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Masahiro KishiInflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital, Chikushino, Japan.
Fumihito HiraiDepartment of Gastroenterology, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan. fuhirai@cis.fukuoka-u.ac.jp.ORCID 0000-0002-5493-5675
Noritaka TakatsuInflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital, Chikushino, Japan.
Takashi HisabeDepartment of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan.
Yasumichi TakadaInflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital, Chikushino, Japan.
Tsuyoshi BeppuInflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital, Chikushino, Japan.
Ken TakeuchiTsujinaka Hospital Kashiwanoha, Kashiwa, Japan.
Makoto NaganumaThe Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Kazuo OhtsukaDepartment of Endoscopy, Tokyo Medical and Dental University, Tokyo, Japan.
Kenji WatanabeCenter for Inflammatory Bowel Disease, Division of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
Takayuki MatsumotoDivision of Gastroenterology, Department of Medicine, Iwate Medical University, Iwate, Japan.
Motohiro EsakiDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Kazutaka KoganeiDepartment of Inflammatory Bowel Disease, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.
Akira SugitaDepartment of Inflammatory Bowel Disease, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.
Keisuke HataNihonbashi Muromachi Mitsui Tower Midtown Clinic, Tokyo, Japan.
Kitarou FutamiDepartment of Surgery, Fukuoka University Chikushi Hospital, Chikushino, Japan.
Yoichi AjiokaDivision of Molecular and Diagnostic Pathology, Graduate School of Medicine and Dental Sciences, Niigata University, Niigata, Japan.
Hiroshi TanabeDepartment of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Akinori IwashitaAII Research Institute of Pathology and Image Diagnosis, Fukuoka, Japan.
Hirotaka ShimizuCenter for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Katsuhiro AraiCenter for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Yasuo SuzukiGinza Central Clinic, Tokyo, Japan.
Tadakazu HisamatsuDepartment of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many clinical trials have been conducted for inflammatory bowel disease (IBD), so various clinical indices (CIs) and endoscopic indices (EIs) have also been evaluated. However, recently, with the progress of IBD management, review of established indices from previous studies, and establishment of new indices, the landscape of the use of indices in clinical trials have changed. We investigated the number and frequency of the indices adapted in recent clinical trials for ulcerative colitis (CI and EI) and Crohn's disease (CI, EI, index related to magnetic resonance imaging, index for evaluating patient-reported outcomes, and health-related quality of life). Based on the results, we selected representative indices and further reviewed their content and characteristics. Moreover, various definitions, including clinical and endoscopic response or remission, have been described by means of representative indices in clinical trials.

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesChronic DiseaseEndoscopyHumansQuality of LifeClinical indexCrohn’s diseaseEndoscopic indexInflammatory bowel diseaseUlcerative colitis

Identifiers

PMID35235037
PMCPMC8938394

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.