ArticleeLife2022
Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Neural timescales from a computational perspective.Nature neuroscience · 2026Review
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- iSTTC: A robust method for accurate estimation of intrinsic neural timescales from single-unit recordings.PLoS computational biology · 2026Article
- Temporal and Spatial Scales of Human Resting-State Cortical Activity across the Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- MRI assessment of intrinsic neural timescales in male alcohol use disorder patients.Frontiers in psychiatry · 2026Article
- Neurons in auditory cortex integrate information within a constrained and context-invariant temporal window.Current biology : CB · 2025Article
- Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence.bioRxiv : the preprint server for biology · 2025Article
- Functional vs anatomical cortico-striatal connectivity in the macaque brain.Translational psychiatry · 2025Article
- Sensory reformatting for a working visual memory.Trends in cognitive sciences · 2025Review
- Convergent and divergent neural and behavioral responses to chronic cocaine use in macaques.bioRxiv : the preprint server for biology · 2025Article
- Network dynamics underlying activity-timescale differences between cortical regions.bioRxiv : the preprint server for biology · 2025Article
- Neurons in auditory cortex integrate information within constrained temporal windows that are invariant to the stimulus context and information rate.bioRxiv : the preprint server for biology · 2025Article
- Brain-wide organization of intrinsic timescales at single-neuron resolution.bioRxiv : the preprint server for biology · 2025Article
- Cognitive processes are disentangled at cortex-wide scales.bioRxiv : the preprint server for biology · 2025Article
- Consistent Hierarchies of Single-Neuron Timescales in Mice, Macaques, and Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sleep Modulates Neural Timescales and Spatiotemporal Integration in the Human Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Network Mechanisms Underlying the Regional Diversity of Variance and Time Scales of the Brain's Spontaneous Activity Fluctuations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hierarchical gradients of multiple timescales in the mammalian forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Timescales of learning in prefrontal cortex.Nature reviews. Neuroscience · 2024Review
- The primate cortical LFP exhibits multiple spectral and temporal gradients and widespread task dependence during visual short-term memory.Journal of neurophysiology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Hierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultrahigh field functional magnetic resonance imaging (fMRI) performed at 10.5 T to probe timescales across the whole macaque brain. We uncovered within-species consistency between timescales estimated from fMRI and electrophysiology. Crucially, we extended existing electrophysiological hierarchies to whole-brain topographies. Our results validate the complementary use of hemodynamic and electrophysiological intrinsic timescales, establishing a basis for future translational work. Further, with these results in hand, we were able to show that one facet of the high-dimensional functional connectivity (FC) topography of any region in the brain is closely related to hierarchical temporal dynamics. We demonstrated that intrinsic timescales are organized along spatial gradients that closely match FC gradient topographies across the whole brain. We conclude that intrinsic timescales are a unifying organizational principle of neural processing across the whole brain.
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Registered trials
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