Evidence map›Paper›PMID 35234601›Full record

ArticleParasitology2022

Schistosomiasis in the People's Republic of China - down but not out.

Catherine A Gordon, Gail M Williams, Darren J Gray, Archie C A Clements, Xiao-Nong Zhou, Yuesheng Li, Jürg Utzinger, Johanna Kurscheid, Simon Forsyth, Kefyalew Addis Alene and 16 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Praziquantel Pretreatment ReducesTropical medicine and infectious disease · 2025
    Article
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 3 countries.

Catherine A GordonDepartment of Immunology, Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0002-1509-5220
Gail M WilliamsSchool of Population Health, Discipline of Epidemiology and Biostatistics, University of Queensland, Brisbane, Australia.
Darren J GrayDepartment of Global Health, Research School of Population Health, Australian National University, Canberra, Australia.
Archie C A ClementsFaculty of Health Sciences, Curtin University, Perth, Australia.
Xiao-Nong ZhouNational Institute of Parasitic Diseases, Shanghai, People's Republic of China.
Yuesheng LiDepartment of Immunology, Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jürg UtzingerSwiss Tropical and Public Health Institute, Basel, Switzerland.
Johanna KurscheidDepartment of Global Health, Research School of Population Health, Australian National University, Canberra, Australia.
Simon ForsythSchool of Population Health, Discipline of Epidemiology and Biostatistics, University of Queensland, Brisbane, Australia.ORCID 0000-0002-3100-3584
Kefyalew Addis AleneFaculty of Health Sciences, Curtin University, Perth, Australia.
Jie ZhouHunan Institute of Schistosomiasis Control, Yueyang, Hunan, People's Republic of China.
Zhaojun LiJiangxi Institute of Parasitic Diseases, Jiangxi, People's Republic of China.
Guangpin LiHunan Institute of Schistosomiasis Control, Yueyang, Hunan, People's Republic of China.
Dandan LinJiangxi Institute of Parasitic Diseases, Jiangxi, People's Republic of China.
Zhihong LouHunan Institute of Schistosomiasis Control, Yueyang, Hunan, People's Republic of China.
Shengming LiHunan Institute of Schistosomiasis Control, Yueyang, Hunan, People's Republic of China.
Jun GeJiangxi Institute of Parasitic Diseases, Jiangxi, People's Republic of China.
Jing XuNational Institute of Parasitic Diseases, Shanghai, People's Republic of China.
Xinling YuHunan Institute of Schistosomiasis Control, Yueyang, Hunan, People's Republic of China.
Fei HuJiangxi Institute of Parasitic Diseases, Jiangxi, People's Republic of China.
Shuying XieJiangxi Institute of Parasitic Diseases, Jiangxi, People's Republic of China.
Jie ChenChinese National Human Genome Center, Shanghai, People's Republic of China.
Tao ShiChinese National Human Genome Center, Shanghai, People's Republic of China.
Chong LiChinese National Human Genome Center, Shanghai, People's Republic of China.
Huajun ZhengChinese National Human Genome Center, Shanghai, People's Republic of China.
Donald P McManusDepartment of Immunology, Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0001-6443-1449
Hunan Institute of Science and Technology · CNJiangsu Institute of Parasitic Diseases · CNChinese National Human Genome Center · CNAustralian National University · AUCurtin University · AUQIMR Berghofer Medical Research Institute · AUThe University of Queensland · AUSwiss Tropical and Public Health Institute · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schistosomiasis has been subjected to extensive control efforts in the People's Republic of China (China) which aims to eliminate the disease by 2030. We describe baseline results of a longitudinal cohort study undertaken in the Dongting and Poyang lakes areas of central China designed to determine the prevalence of Schistosoma japonicum in humans, animals (goats and bovines) and Oncomelania snails utilizing molecular diagnostics procedures. Data from the Chinese National Schistosomiasis Control Programme (CNSCP) were compared with the molecular results obtained.Sixteen villages from Hunan and Jiangxi provinces were surveyed; animals were only found in Hunan. The prevalence of schistosomiasis in humans was 1.8% in Jiangxi and 8.0% in Hunan determined by real-time polymerase chain reaction (PCR), while 18.3% of animals were positive by digital droplet PCR. The CNSCP data indicated that all villages harboured S. japonicum-infected individuals, detected serologically by indirect haemagglutination assay (IHA), but very few, if any, of these were subsequently positive by Kato-Katz (KK).Based on the outcome of the IHA and KK results, the CNSCP incorporates targeted human praziquantel chemotherapy but this approach can miss some infections as evidenced by the results reported here. Sensitive molecular diagnostics can play a key role in the elimination of schistosomiasis in China and inform control measures allowing for a more systematic approach to treatment.

Indexed as

Schistosoma japonicumSchistosomiasisSchistosomiasis japonicaAnimalsCattleChinaHumansLongitudinal StudiesPrevalenceReal-Time Polymerase Chain ReactionSnailsChinese National Schistosomiasis Control Programmedigital droplet PCR (ddPCR)Dongting lakeHunan provinceJiangxi provinceKato-KatzLAMPPeople's Republic of ChinaPoyang lakeReal-time PCR (qPCR)Schistosoma japonicumSchistosomiasis

Identifiers

PMID35234601
PMCPMC11010531
OpenAlexW3210017638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.