ArticleEmerging microbes & infections2022
Human infection with avian-origin H5N6 influenza a virus after exposure to slaughtered poultry.
Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Transmission Pathways of Zoonotic Influenza Viruses and Influencing Factors: A Systematic Review of Recent Findings.Viruses · 2025Pooled it
- Epidemiological characterization of human infection with H5N6 avian influenza.Frontiers in public health · 2024Pooled it
- Public health risks and control measures associated with live animal and animal product trade in traditional food markets in low- and middle-income countries: a scoping review.BMJ public health · 2026Article
- Avian influenza and coronaviruses in live animal and wet markets in Laos: prevalence and public health considerations.Frontiers in cellular and infection microbiology · 2026Article
- A Rapid Review Contrasting the Evidence on Avian Influenza A(H5Nx) Clades 2.3.4.4b and 2.3.2.1c in Humans.Zoonoses and public health · 2025Review
- Investigation of human infection with H5N6 avian influenza cases in Sichuan Province from 2014 to 2024: a retrospective study.Frontiers in public health · 2025Article
- The H5N6 Virus Containing Internal Genes From H9N2 Exhibits Enhanced Pathogenicity and Transmissibility.Transboundary and emerging diseases · 2025Article
- A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage.Emerging microbes & infections · 2024Article
- Severe pneumonia with co-infection of H5N1 and SARS-CoV-2: a case report.BMC infectious diseases · 2024Article
- Epidemiological characteristics of human infections with avian influenza A(H5N6) virus, China and Laos: A multiple case descriptive analysis, February 2014-June 2023.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2024Article
- Clade 2.3.4.4 H5 chimeric cold-adapted attenuated influenza vaccines induced cross-reactive protection in mice and ferrets.Journal of virology · 2023Article
- Avian influenza overview June-September 2023.EFSA journal. European Food Safety Authority · 2023Article
- Culture-Independent Workflow for Nanopore MinION-Based Sequencing of Influenza A Virus.Microbiology spectrum · 2023Article
- Translating conventional wisdom on chicken comb color into automated monitoring of disease-infected chicken using chromaticity-based machine learning models.Frontiers in veterinary science · 2023Article
- Histone deacetylase 6's function in viral infection, innate immunity, and disease: latest advances.Frontiers in immunology · 2023Review
- Clinical features of the first critical case of acute encephalitis caused by the avian influenza A (H5N6) virus.Emerging microbes & infections · 2022Article
- Etiologic characteristics of avian influenza H11 viruses isolated from the live poultry market in southeast coastal region in China.Frontiers in microbiology · 2022Article
- Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs- focus on the bigger picture.Frontiers in immunology · 2022Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to poultry in live poultry markets is strongly associated with human infection with avian influenza virus. To effectively prevent the transmission of viruses from live poultry to humans, people have been forced to change their living habits from purchasing live poultry for consumption to purchasing freshly slaughtered poultry after the permanent closure of live poultry markets in China. In this study, we reported a case of human infection by the H5N6 virus in Hangzhou after exposure to a freshly slaughtered chicken, defying the traditional hypothesis that human infection requires a history of exposure to live poultry and indicating a novel route of infection. Rapid genomic characterization of H5N6 influenza A variants from the patient and the associated environment suggested that these viral variants were of avian origin, belonged to clade 2.3.4.4b H5 and were adapting to the human host after infection. Comparative analysis of the local H5N6 genomes showed that viral contamination in the associated environment and the poultry market was complex. Considering this case of H5N6 infection, conducting surveillance for any possible new avian influenza virus reassortment spillover to humans or other animal species is critical, and awareness of the risk of exposure to possible viral variants from infected slaughtered poultry or the associated environment must be seriously improved.
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