Evidence map›Paper›PMID 35234139›Full record

ArticleActa crystallographica. Section F, Structural biology communications2022

Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx.

Jasmine Maddy, Bart L Staker, Sandhya Subramanian, Jan Abendroth, Thomas E Edwards, Peter J Myler, Kevin Hybiske, Oluwatoyin A Asojo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jasmine MaddyDepartment of Chemistry and Biochemistry, Hampton University, 100 East Queen Street, Hampton, VA 23668, USA.
Bart L StakerCenter for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA.
Sandhya SubramanianCenter for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA.
Jan AbendrothSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.ORCID 0000-0002-8229-3243
Thomas E EdwardsSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.ORCID 0000-0002-0474-8003
Peter J MylerCenter for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA.ORCID 0000-0002-0056-0513
Kevin HybiskeDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Oluwatoyin A AsojoDepartment of Chemistry and Biochemistry, Hampton University, 100 East Queen Street, Hampton, VA 23668, USA.ORCID 0000-0002-4043-2700
Center for Infectious Disease Research · USHampton University · USUniversity of Washington · US

Funding

U-RISE at Hampton UniversityT34GM136489 · NIGMS · HAMPTON UNIVERSITY · PI EREBHOLO, FRANCIS, NJOKI, PETER · 2020 to 2024
$1.5M
HU-CHEM: Deploying evidence-based interventions in Chemistry at Hampton University to plug leaks in the biomedical training pipelineU01GM138433 · NIGMS · HAMPTON UNIVERSITY · PI ASOJO, OLUWATOYIN AJIBOLA · 2020 to 2022
$1.1M
NIAID NIH HHS HHSN272200700057CNIAID NIH HHS HHSN272201200025CNIAID NIH HHS HHSN272201700059CNIGMS NIH HHS 1U01GM138433NIGMS NIH HHS T34 GM136489NIGMS NIH HHS T34GM136489NIGMS NIH HHS U01 GM138433
6 · The paper itself

Abstract

Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections globally and is one of the most commonly reported infections in the United States. There is a need to develop new therapeutics due to drug resistance and the failure of current treatments to clear persistent infections. Structures of potential C. trachomatis rational drug-discovery targets, including C. trachomatis inorganic pyrophosphatase (CtPPase), have been determined by the Seattle Structural Genomics Center for Infectious Disease. Inorganic pyrophosphatase hydrolyzes inorganic pyrophosphate during metabolism. Furthermore, bacterial inorganic pyrophosphatases have shown promise for therapeutic discovery. Here, a 2.2 Å resolution X-ray structure of CtPPase is reported. The crystal structure of CtPPase reveals shared structural features that may facilitate the repurposing of inhibitors identified for bacterial inorganic pyrophosphatases as starting points for new therapeutics for C. trachomatis.

Indexed as

Chlamydia trachomatisInorganic PyrophosphataseCrystallography, X-RayUnited StatesInorganic PyrophosphataseChlamydia trachomatisinfectious diseasesinorganic pyrophosphataseSeattle Structural Genomics Center for Infectious Diseaseundergraduate education and training

Identifiers

PMID35234139
PMCPMC8900733
OpenAlexW4214573254

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.