Evidence map›Paper›PMID 35234023›Full record

SynthesisJBRA assisted reproduction2022

The most important medicinal plants affecting sperm and testosterone production: a systematic review.

Shakiba Nasiri Boroujeni, Farid Ansari Malamiri, Fatemeh Bossaghzadeh, Alireza Esmaeili, Emadoddin Moudi

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in JBRA assisted reproduction, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07109622 (A Randomized, Double-blind, Placebo-controlled Pilot Study to Evaluate the Efficacy of LN18178 on Improving Sperm Virility), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07109622 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Randomized, Double-blind, Placebo-controlled Pilot Study to Evaluate the Efficacy of LN18178 on Improving Sperm Virility (Sperm Motility, Sperm Concentration, and Sperm Morphology)

TypeinterventionalSponsorGENCOR Lifestage SolutionsRan2025 to 2026Enrolled40ConditionsHealthy Human VolunteersArmsLN18178, Placebo
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Effects ofNutrients · 2023
    Pooled it
  2. Article
  3. Reproductive and immune-related consequences ofFrontiers in veterinary science · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Unveiling the Neuroprotective Potential of Date Palm (Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  10. Article
  11. Effects of Chicory (Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  12. Can Ashwagandha Benefit the Endocrine System?-A Review.International journal of molecular sciences · 2023
    Review
  13. Protective Effect ofCurrent issues in molecular biology · 2023
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Shakiba Nasiri BoroujeniMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Farid Ansari MalamiriFaculty of Veterinary Medicine, Islamic Azad University of Shahrekord, Shahrekord, Iran.
Fatemeh BossaghzadehDepartment of Biology, Dezful Branch, Islamic Azad University, Dezful, Iran and Student Research Committee, Dezful Branch, Islamic Azad University, Dezful, Iran.
Alireza EsmaeiliNon-Communicable Disease Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Emadoddin MoudiAssociate Professor, Department of Urology, Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Babol University of Medical Sciences · IRIslamic Azad University, Dezful Branch · IRIslamic Azad University of Shahrekord · IRMedical University of Ilam · IRShahrekord University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveInfertility, defined as the inability to conceive after one year of intercourse without the use of contraception, affects 15% of couples. Many factors, such as genitourinary tract infections, endocrine disorders, immunological factors and drug-related injuries, affect the male reproductive system and cause infertility. Due to men's fear of infertility, it is very important to pay attention to medicinal plants that are effective in male fertility. Therefore, the aim of this study was to evaluate the medicinal plants that affect sperm and testosterone production in men.

methodsIn this review, we used the following search terms, consisting of herbal medicine, traditional medicine, traditional therapies, sperm, testosterone, testicles and Iran were used to retrieve the relevant articles published in the journals indexed in the Information Sciences Institute, Science Direct, PubMed, Scopus, PubMed Central and Scientific Information Databases. We searched and used papers published between 2000 and 2020. Then, we analyzed the eligible papers. We collected and analyzed 35 papers from the databases. We selected only the articles about herbs that affect sperm and testosterone production.

resultsBased on the results, herbs Apium graveolens, Cinnamomum camphora, Cornus mas, Satureja khuzestanica, Withania somnifera, Fumaria parviflora, zingiber officinale, cinnamomum zeylanicum and Phoenix dactylifera are used in the male reproductive system.

conclusionsPlants can probably be useful in increasing fertility due to their antioxidant power and low side effects.

Indexed as

InfertilityPlants, MedicinalHumansMaleSeedsSpermatozoaTestosteroneTestosteroneherbIransperm productiontesticlestestosteronetraditional medicine

Identifiers

PMID35234023
PMCPMC9355441
OpenAlexW4205856214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.