Evidence map›Paper›PMID 35233968›Full record

ArticleLower urinary tract symptoms2022

Does urinary urgency drive urinary frequency in overactive bladder?

Eboo Versi, Eric S Rovner, Roger R Dmochowski, Le Mai Tu, Stefan De Wachter

Abstract read
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In one paragraph

Article in Lower urinary tract symptoms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Eboo VersiDepartment of Obstetrics, Gynecology, Reproductive Sciences, Rutgers, New Brunswick, New Jersey, USA.ORCID https://orcid.org/0000-0001-9366-7370
Eric S RovnerDepartment of Urology, Medical University of South Carolina, Charleston, South Carolina, USA.
Roger R DmochowskiDepartment of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Le Mai TuDivision of Urology, Department of Surgery, Sherbrooke University Hospital, Sherbrooke, Quebec, Canada.
Stefan De WachterDepartment of Urology, Antwerp University Hospital and Faculty of Medicine, University of Antwerp, Antwerp, Belgium.
Medical University of South Carolina · USRutgers, The State University of New Jersey · USUniversité de Sherbrooke · CAUniversity of Antwerp · BEVanderbilt University Medical Center · US

Funding

Hologic Inc. paid for the medical writers but did not influence the content of the manuscript nor did the company review the submitted manuscript.
6 · The paper itself

Abstract

objectivesTo determine if reduction in urgency in patients with refractory overactive bladder syndrome (rOAB) is correlated with a reduction in voiding frequency and symptom bother.

methodsData from a prospective series of women with rOAB undergoing radiofrequency ablation of the subtrigonal tissue, termed selective bladder denervation (SBD), was analyzed. Main outcome measures included urgency voids, nonurgency voids, and urgency urinary incontinence (UUI) epidsodes from a 3-day voiding diary and quality of life (QoL) measures (Overactive Bladder Questionnaire Short Form [OAB-q SF]).

resultsThe dataset comprised 62 completer subjects at 6 months. Compared to baseline, UUI and urgency voids were lower (P < .001), but nonurgency voids were increased (P < .001) and QoL measures were improved (P < .001), but functional bladder capacity did not increase. At baseline and 6 months post treatment, symptom bother was correlated with urgency voids (P < .05) but inversely correlated with nonurgency voids (P < .001). Urgency and nonurgency voids were inversely related at baseline and at 6 months (P < .0001). Following treatment, urgency voids decreased by 41% and nonurgency voids increased by 33%.

conclusionsAs with other interventions for OAB, SBD resulted in a reduction in OAB symptoms and an improvement in QoL measures. However, the decrease in urgency voids was offset by an increase in nonurgency voids, suggesting that habit or defensive voiding is a significant driver of urinary frequency. It is not certain if this is a unique finding of the SBD effect, but these data do suggest that analyses of outcomes of other OAB interventions are warranted to gain a better understanding of the genesis of OAB symptoms.

Indexed as

Urinary Bladder, OveractiveUrinary IncontinenceFemaleHumansProspective StudiesQuality of LifeTreatment OutcomeUrinary Incontinence, Urgenonurgency voidsQoLradiofrequency ablationrefractory OABtrigoneurgencyvoiding frequency

Identifiers

PMID35233968
OpenAlexW4214599506

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.