Evidence map›Paper›PMID 35233730›Full record

ArticlePharmaceutical research2022

Photoisomerization of Sulindac and Ozagrel Hydrochloride by Vitamin B

Mayuko Suga, Kosho Makino, Hidetsugu Tabata, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The evaluation of photochemical behavior of antihistaminic drug triprolidine in an aqueous media.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mayuko SugaDepartment of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641Yamazaki, Noda-shi, Chiba, 278-8510, Japan.
Kosho MakinoDepartment of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641Yamazaki, Noda-shi, Chiba, 278-8510, Japan.
Hidetsugu TabataDepartment of Medicinal Chemistry, Faculty of Pharma Sciences, Teikyo University, Itabashi-ku, Tokyo, Japan.
Tetsuta OshitariDepartment of Medicinal Chemistry, Faculty of Pharma Sciences, Teikyo University, Itabashi-ku, Tokyo, Japan.
Hideaki NatsugariDepartment of Medicinal Chemistry, Graduate School of Pharmaceutical Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Hideyo TakahashiDepartment of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641Yamazaki, Noda-shi, Chiba, 278-8510, Japan. hide-tak@rs.tus.ac.jp.ORCID http://orcid.org/0000-0001-5965-3987
Tokyo University of Science · JPTeikyo University · JPThe University of Tokyo · JP

Funding

Japan Society for the Promotion of Science 19K16454
6 · The paper itself

Abstract

purposePhotoisomerization of the E/Z-alkene structures of drugs is a matter of concern as it could result in potency loss and adverse side effects. This study focused on light-induced isomerization of sulindac and ozagrel hydrochloride catalyzed by concomitant vitamin B

methodsIn the presence of 0.05/0.03 equivalents of vitamin B

resultsSulindac and ozagrel hydrochloride isomerized in the presence of a catalytic amount of vitamin B

conclusionThe catalytic activity of vitamin B

Indexed as

MethacrylatesPhotochemical ProcessesSulindacCatalysisFlavin-Adenine DinucleotideIsomerismLightRiboflavinFlavin-Adenine DinucleotideMethacrylatesozagrelRiboflavinSulindacozagrelphotoisomerizationriboflavinsulindacvitamin B2

Identifiers

PMID35233730
OpenAlexW4214900179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.