Evidence map›Paper›PMID 35233577›Full record

ArticlebioRxiv : the preprint server for biology2023

Type I interferon responsive microglia shape cortical development and behavior.

Caroline C Escoubas, Leah C Dorman, Phi T Nguyen, Christian Lagares-Linares, Haruna Nakajo, Sarah R Anderson, Beatriz Cuevas, Ilia D Vainchtein, Nicholas J Silva, Yinghong Xiao and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 24 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Caroline C EscoubasDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Leah C DormanDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Phi T NguyenDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Christian Lagares-LinaresDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Haruna NakajoDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Sarah R AndersonDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Beatriz CuevasDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Ilia D VainchteinDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Nicholas J SilvaDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Yinghong XiaoDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.
Peter V LidskyDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.
Ellen Y WangDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Sunrae E TalomaDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Hiromi Nakao-InoueDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Bjoern SchwerKavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA.
Raul AndinoDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.
Tomasz J NowakowskiDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
Anna V MolofskyDepartment of Psychiatry and Behavioral Sciences/ Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
University of California, San Francisco · US

Funding

UCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Coordinate regulation of neural circuit remodeling by glia: a prospective molecular approachDP2MH116507 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ANNA V · 2017 to 2017
$2.4M
Mapping Developmental Lineage Relationships in the Cerebral CortexRF1MH121268 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOWAKOWSKI, TOMASZ · 2019 to 2019
$2.1M
Astrocyte-microglial communication in developmental synapse formationR01MH119349 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ANNA V · 2019 to 2023
$2.0M
Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's DiseaseRF1AG061874 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CONDELLO, CARLO L, DEGRADO, WILLIAM · 2018 to 2018
$2.0M
NIAID NIH HHS T32 AI007334NIA NIH HHS RF1 AG061874NIGMS NIH HHS K12 GM081266NIMH NIH HHS DP2 MH116507NIMH NIH HHS R01 MH119349NIMH NIH HHS RF1 MH121268
6 · The paper itself

Abstract

Microglia are brain resident phagocytes that can engulf synaptic components and extracellular matrix as well as whole neurons. However, whether there are unique molecular mechanisms that regulate these distinct phagocytic states is unknown. Here we define a molecularly distinct microglial subset whose function is to engulf neurons in the developing brain. We transcriptomically identified a cluster of Type I interferon (IFN-I) responsive microglia that expanded 20-fold in the postnatal day 5 somatosensory cortex after partial whisker deprivation, a stressor that accelerates neural circuit remodeling.

Identifiers

PMID35233577
PMCPMC8887080
OpenAlexW3157611710

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.