ArticleInnovation in aging2022
Trajectories of Frailty With Aging: Coordinated Analysis of Five Longitudinal Studies.
Article in Innovation in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 27 citations in OpenAlex.
- The Effectiveness of an App-Based Fitness Program on Self-Perceived Physical Functioning in Older Adults: Randomized Waitlist-Controlled Trial.Journal of medical Internet research · 2025Trial
- Article
- Factors associated with sustained robustness in older adults: an 8-year multinational longitudinal study using SHARE data.BMC geriatrics · 2026Observational
- Dynamic frailty trajectories and risk of chronic obstructive pulmonary disease: a large-scale prospective cohort study.BMC pulmonary medicine · 2026Article
- Longitudinal norms of frailty measured by the frailty index: A cross-national comparison using data from the survey of health, aging, and retirement in Europe (SHARE).The Journal of frailty & aging · 2026Observational
- SK channel upregulation and sex-specific mechanisms drive spinal motoneuron reduced excitability with age.Frontiers in aging neuroscience · 2026Article
- Association of healthy lifestyle patterns with changes in physical frailty and subjective cognitive function among community-dwelling older adults: a 3-year longitudinal study.BMC geriatrics · 2025Article
- Skilled Nursing Facility Population Characteristics and Length of Stay: A Prospective Cohort Study.Journal of the American Medical Directors Association · 2025Article
- A survey on the trajectory of frailty in the middle-aged and elderly population in the Chengdu community: a retrospective observational study.BMC public health · 2025Observational
- Two decades of end-of-life conditions of older adults: older and more protracted?SSM - population health · 2025Article
- Infections and cognitive function, depression, and frailty: a cross-sectional study in the longitudinal aging study in India (LASI).BMC public health · 2025Article
- Sex and Age-Related Changes in Lean Mass of C57BL/6 Mice: A New Method for Assessing Body Composition.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- The Longitudinal Aging Study Amsterdam: design and cohort update 2025.European journal of epidemiology · 2025Article
- Frailty in older adults patients: a prospective observational cohort study on subtype identification.European journal of medical research · 2025Observational
- The development of frailty trajectories in world trade center general responders and the association with World Trade Center Exposure.The Journal of frailty & aging · 2025Article
- Frailty in motion: Amnestic mild cognitive impairment and Alzheimer's disease cohorts display heterogeneity in multimorbidity classification and longitudinal transitions.Journal of Alzheimer's disease : JAD · 2025Article
- Frailty trajectories and their determinants in cancer patients undergoing immunotherapy: a prospective longitudinal study.Frontiers in oncology · 2025Article
- From curing to caring: exploring social care needs after the onset of chronic conditions among European older adults (50+).Innovation in aging · 2025Article
- Short-term Frailty Index Fluctuations in Older Adults: Noise or Signal?The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Secular trends in frailty among community-dwelling 75-95-year-old cohorts over three decades in Helsinki, Finland.Age and ageing · 2024Article
Corrections and comments
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Authors and funding
23 authors at 14 institutions in 7 countries.
Funding
Abstract
BACKGROUND AND
objectivesThere is an urgent need to better understand frailty and its predisposing factors. Although numerous cross-sectional studies have identified various risk and protective factors of frailty, there is a limited understanding of longitudinal frailty progression. Furthermore, discrepancies in the methodologies of these studies hamper comparability of results. Here, we use a coordinated analytical approach in 5 independent cohorts to evaluate longitudinal trajectories of frailty and the effect of 3 previously identified critical risk factors: sex, age, and education. RESEARCH DESIGN AND
methodsWe derived a frailty index (FI) for 5 cohorts based on the accumulation of deficits approach. Four linear and quadratic growth curve models were fit in each cohort independently. Models were adjusted for sex/gender, age, years of education, and a sex/gender-by-age interaction term.
resultsModels describing linear progression of frailty best fit the data. Annual increases in FI ranged from 0.002 in the Invecchiare in Chianti cohort to 0.009 in the Longitudinal Aging Study Amsterdam (LASA). Women had consistently higher levels of frailty than men in all cohorts, ranging from an increase in the mean FI in women from 0.014 in the Health and Retirement Study cohort to 0.046 in the LASA cohort. However, the associations between sex/gender and rate of frailty progression were mixed. There was significant heterogeneity in within-person trajectories of frailty about the mean curves. DISCUSSION AND IMPLICATIONS: Our findings of linear longitudinal increases in frailty highlight important avenues for future research. Specifically, we encourage further research to identify potential effect modifiers or groups that would benefit from targeted or personalized interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.