ArticleACS central science2022
NP Analyst: An Open Online Platform for Compound Activity Mapping.
Article in ACS central science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- FERMO: A Dashboard for Biochemometric Prioritization of Molecular Features from Mass Spectral Data.ACS measurement science au · 2026Article
- Kineochelins-A New Group of Siderophores From an Antarctic Bacterium.Microbial biotechnology · 2026Article
- Article
- Molecules to medicine: advances in metabolomics for natural product drug discovery.Current opinion in biotechnology · 2025Review
- Chemodiversity of Cyanobacteria from Brazil Investigated by Metabolomics and Bioassays.ACS omega · 2025Article
- PLANTA Protocol for the Direct Detection and Identification of Bioactive Compounds in Complex Mixtures via Combined NMR-HPTLC-Based Heterocovariance.Analytical chemistry · 2025Article
- Prediction of Bioactive Metabolites from AmericanJournal of natural products · 2025Article
- Harnessing Molecular and Bioactivity Network Analysis to Prioritize Antibacterial Compound Isolation From Ant-Associated Fungi.Phytochemical analysis : PCA · 2025Article
- Effective data visualization strategies in untargeted metabolomics.Natural product reports · 2025Review
- The Phytochemistry and Pharmacology of Onocleaceae Plants:Plants (Basel, Switzerland) · 2025Review
- Combining the Strengths of MS and NMR in Biochemometrics: A Case Study onJournal of natural products · 2025Article
- Integrative metabolo-genomics suggests a biosynthetic pathway for tetrangulol in Streptomyces sp. KL110A.World journal of microbiology & biotechnology · 2025Article
- HPTLC Combined with sHetCA and Multivariate Statistics for the Detection of Bioactive Compounds in Complex Mixtures.Molecules (Basel, Switzerland) · 2024Article
- Primed for Discovery.Biochemistry · 2024Review
- Accessing the specialized metabolome of actinobacteria from the bulk soil of Paullinia cupana Mart. on the Brazilian Amazon: a promising source of bioactive compounds against soybean phytopathogens.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides.Nature communications · 2024Article
- Interplay of emerging and established technologies drives innovation in natural product antibiotic discovery.Current opinion in microbiology · 2023Review
- Functional annotation map of natural compounds in traditional Chinese medicines library: TCMs with myocardial protection as a case.Acta pharmaceutica Sinica. B · 2023Article
- MultiplexMS: A Mass Spectrometry-Based Multiplexing Strategy for Ultra-High-Throughput Analysis of Complex Mixtures.Analytical chemistry · 2023Article
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few tools exist in natural products discovery to integrate biological screening and untargeted mass spectrometry data at the library scale. Previously, we reported Compound Activity Mapping as a strategy for predicting compound bioactivity profiles directly from primary screening results on extract libraries. We now present NP Analyst, an open online platform for Compound Activity Mapping that accepts bioassay data of almost any type, and is compatible with mass spectrometry data from major instrument manufacturers via the mzML format. In addition, NP Analyst will accept processed mass spectrometry data from the MZmine 2 and GNPS open-source platforms, making it a versatile tool for integration with existing discovery workflows. We demonstrate the utility of this new tool for both the dereplication of known compounds and the discovery of novel bioactive natural products using a challenging low-resolution antimicrobial bioassay data set. This new platform is available at www.npanalyst.org.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.