Evidence map›Paper›PMID 35233442›Full record

ArticleInternational journal of cardiology. Heart & vasculature2022

Echocardiographic predictors of mortality and morbidity in COVID-19 disease using focused cardiovascular ultrasound.

Joanne Michelle D Gomez, Allison C Zimmerman, Jeanne du Fay de Lavallaz, John Wagner, Lillian Tung, Athina Bouroukas, Tai Tri P Nguyen, Jessica Canzolino, Alan Goldberg, Annabelle Santos Volgman and 2 more

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Article in International journal of cardiology. Heart & vasculature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joanne Michelle D GomezCedars-Sinai Medical Center, Department of Cardiology, 127 S. San Vicente Boulevard, Advanced Health Sciences Pavilion 9305, Los Angeles, CA 90048, USA.
Allison C ZimmermanHenry Ford Hospital, Department of Internal Medicine, Division of Cardiology, 2799 W. Grand Boulevard, K14, Detroit, MI 48202, USA.
Jeanne du Fay de LavallazUniversity Hospital of Basel, Department of Cardiology, Petersgraben 4, 4051 Basel, Switzerland.
John WagnerRush University Medical Center, Department of Internal Medicine, Armour Academic Center, 600 S. Paulina Street, Suite 403, Chicago, IL 60612, USA.
Lillian TungRush University Medical Center, Department of Internal Medicine, Armour Academic Center, 600 S. Paulina Street, Suite 403, Chicago, IL 60612, USA.
Athina BouroukasRush University Medical Center, Department of Internal Medicine, Armour Academic Center, 600 S. Paulina Street, Suite 403, Chicago, IL 60612, USA.
Tai Tri P NguyenRush University Medical Center, Department of Internal Medicine, Armour Academic Center, 600 S. Paulina Street, Suite 403, Chicago, IL 60612, USA.
Jessica CanzolinoRush University Medical Center, Department of Internal Medicine, Division of Cardiology, 1717 W. Congress Parkway, Chicago, IL 60612, USA.
Alan GoldbergRush University Medical Center, Department of Internal Medicine, Division of Cardiology, 1717 W. Congress Parkway, Chicago, IL 60612, USA.
Annabelle Santos VolgmanRush University Medical Center, Department of Internal Medicine, Division of Cardiology, 1717 W. Congress Parkway, Chicago, IL 60612, USA.
Tisha SubocRush University Medical Center, Department of Internal Medicine, Division of Cardiology, 1717 W. Congress Parkway, Chicago, IL 60612, USA.
Anupama K RaoRush University Medical Center, Department of Internal Medicine, Division of Cardiology, 1717 W. Congress Parkway, Chicago, IL 60612, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFocused transthoracic echocardiography (fTTE) has emerged as a critical diagnostic tool during the COVID-19 pandemic, allowing for efficient cardiac imaging while minimizing staff exposure. The utility of fTTE in predicting clinical outcomes in COVID-19 remains under investigation.

methodsWe conducted a retrospective study of 2,266 hospitalized patients at Rush University Medical Center with COVID-19 infection between March and November 2020 who received a fTTE. fTTE data were analyzed for association with primary adverse outcomes (60-day mortality) and with secondary adverse outcomes (need for renal replacement therapy, need for invasive ventilation, shock, and venous thromboembolism).

resultsOf the 427 hospitalized patients who had a fTTE performed (mean 62 years, 43% female), 109 (26%) had died by 60 days. Among patients with an available fTTE measurement, right ventricular (RV) dilation was noted in 34% (106/309), 43% (166/386) had RV dysfunction, and 17% (72/421) had left ventricular (LV) dysfunction. In multivariable models accounting for fTTE data, RV dilation was significantly associated with 60-day mortality (OR 1.93 [CI 1.13-3.3], p = 0.016). LV dysfunction was not significantly associated with 60-day mortality (OR 0.95 [CI: 0.51-1.78], p = 0.87).

conclusionsAbnormalities in RV echocardiographic parameters are adverse prognosticators in COVID-19 disease. Patients with RV dilation experienced double the risk for 60-day mortality due to COVID-19. To our knowledge, this is the largest study to date that highlights the adverse prognostic implications of RV dilation as determined through fTTE in hospitalized COVID-19 patients.

Indexed as

ACE2, angiotensin-converting enzyme 2ARDS, acute respiratory distress syndromeASE, American Society of EchocardiographyBNP, B-type natriuretic peptideCCE, critical care echocardiographyCI, confidence intervalCOVID-19COVID-19, coronavirus disease 2019EchocardiographyfTTE, focused transthoracic echocardiographyGLS, global longitudinal strainIQR, interquartile rangeIRB, institutional review boardLVEDD, left ventricular end diastolic diameterLVEF, left ventricular ejection fractionLV, left ventricle / left ventricularMortalityOR, odds ratioPA, pulmonary arteryPCR, polymerase chain reactionPLAX, parasternal long-axis viewPOCUS, point-of-care ultrasoundPPE, personal protective equipmentPrognosisPSAX, parasternal short-axis viewPUI, patient under investigationRRT, renal replacement therapyRVLS, right ventricular longitudinal strainRV, right ventricle / right ventricularSARS-CoV-2, novel SARS coronavirusS’, peak lateral tricuspid annular systolic velocityTAPSE, tricuspid annular plane systolic excursion

Identifiers

PMID35233442
PMCPMC8872842

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.