Evidence map›Paper›PMID 35233387›Full record

ArticleJournal of clinical and translational hepatology2022

Autoimmune Hepatitis Induced after Treatment of Syphilitic Hepatitis.

Hasan Ali, Taqi Rizvi, Mumtaz Niazi, Mark Galan, Nikolaos Pyrsopoulos

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and translational hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hasan AliDepartment of Internal Medicine, Rutgers University New Jersey Medical School, Newark, NJ, USA.ORCID https://orcid.org/0000-0001-5726-5657
Taqi RizviEdward Via College of Osteopathic Medicine, Spartanburg, SC, USA.
Mumtaz NiaziDivision of Gastroenterology and Hepatology, Rutgers University New Jersey Medical School, Newark, NJ, USA.
Mark GalanDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers University New Jersey Medical School, Newark, NJ, USA.
Nikolaos PyrsopoulosDivision of Gastroenterology and Hepatology, Rutgers University New Jersey Medical School, Newark, NJ, USA.
Rutgers, The State University of New Jersey · USEdward Via College of Osteopathic Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a unique case of biopsy-proven syphilitic hepatitis which presented as severe acute liver injury with significant elevation in aminotransferases and bilirubin, and improved with antibiotic therapy. However, the patient returned weeks after initial presentation with new-onset acute liver injury and had developed hypergammaglobulinemia, positive autoantibody titers, and repeat liver biopsy demonstrating interface hepatitis, supporting a diagnosis of autoimmune hepatitis. He had an otherwise unrevealing etiologic workup, and responded to glucocorticoid therapy. We believe that syphilitic hepatitis and its treatment subsequently triggered an immunogenic response, leading to autoimmune hepatitis. Autoimmune hepatitis is a chronic liver disease thought to manifest as a result of predisposing genetic factors in combination with environmental insults, especially hepatotropic pathogens. Syphilis is a sexually transmitted disease caused by

Indexed as

Autoimmune hepatitisMolecular mimicrySyphilis

Identifiers

PMID35233387
PMCPMC8845154
OpenAlexW3172451077

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.