ArticleJournal of clinical and translational hepatology2022
Identification of Expression Pattern and Clinical Significance of the Small Cajal Body-specific RNA SCARNA16 in Hepatocellular Carcinoma.
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- Oncogene SCARNA12 as a potential diagnostic biomarker for colorectal cancer.Molecular biomedicine · 2023Article
- Midsize noncoding RNAs in cancers: a new division that clarifies the world of noncoding RNA or an unnecessary chaos?Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Review
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15 authors at 2 institutions in 2 countries.
Sitong ZhangDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0003-2909-0858
Yuan DingDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.
Zhongquan SunDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.
Yao GeKey Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.
Yanjie LiDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-6517-5085
Xin HanDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0001-5282-9927
Qianhui XuDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0001-6035-1687
Liuzhi ZhouDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-9562-8073
Yining ChenDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-0037-4833
Hao XuDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-2169-115X
Yang BaiDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0003-0521-4406
Chang XuDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.
Hao DingDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0001-8417-4144
Sheng YanDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-4153-3546
Weilin WangDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0001-9432-2649
Pancreas Centre (Canada) · CAZhejiang University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsFor high morbidity and mortality, hepatocellular carcinoma (HCC) becomes a major health issue worldwide. Nowadays, numerous non-coding RNAs (ncRNAs) are known to regulate the occurrence and pathogenesis of tumors. Some ncRNAs have also been developed as tumor biomarkers and therapeutic targets. However, the potential function of the small Cajal body-specific RNA (scaRNA) SCARNA16, a newly identified ncRNA, remains to be explored in HCC.
methodsIn both HCC cell lines and specimens from 120 enrolled patients, the expression values of SCARNA16 were detected. We divided patients into SCARNA16 high and low expression subgroups, and then analyzed the difference of various clinical characteristics and prognosis data between subgroups.
resultsCompared to paired controls, SCARNA16 was significantly down-regulated in HCC cell lines and clinical specimens (
conclusionsLow expression patterns of SCARNA16 remarkably associated with severe clinical status and poor survival of patients, suggesting that SCARNA16 possesses potency as a novel biomarker for HCC.
Indexed as
BiomarkerClinical assessmentHepatocellular carcinomaNon-coding RNASCARNA16
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