ArticleScientific reports2022
Hypothyroidism and related comorbidities on the risks of developing tinnitus.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Audiovestibular Dysfunction in Patients with Hashimoto's Disease: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Inner Ear Dysfunction in Thyroid Disease: A Scoping Review.Medicina (Kaunas, Lithuania) · 2025Article
- Dynamic Changes in Free Triiodothyronine (FT3) and Their Correlation with Hearing Recovery in Sudden Sensorineural Hearing Loss: Clinical Implications.Journal of otology · 2025Article
- Tinnitus and Its Comorbidities: A Comprehensive Analysis of Their Relationships.Journal of clinical medicine · 2025Article
- The link between tinnitus and menstrual cycle disorders in premenopausal women.Scientific reports · 2025Article
- Astrocytes and Tinnitus.Brain sciences · 2024Review
- Statistical Associations between Vestibular Pathologies and Hypothyroidism: A Retrospective Study.Journal of clinical medicine · 2024Article
- Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study.Journal of clinical medicine · 2022Article
- The First 100 Children Treated in a Newly Established Pediatric Vertigo Center.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This is a retrospective longitudinal study that uses data from the National Health Insurance Research Database (NHIRD) of Taiwan of which hypothyroid patients who received a diagnosis between 2000 and 2010 were selected and followed up until 2011. The primary outcome of this study was the occurrence of tinnitus (ICD-9-CM code 388.3). The relevant comorbidities were selected as potential confounders according to the literature, which included vertigo (ICD-9-CM code 386), insomnia (ICD-9-CM code 780), anxiety (ICD-9-CM code 300.00), and hearing loss (ICD-9-CM code 388-389). The overall incidence of tinnitus was significantly higher in the hypothyroidism cohort than in the non-hypothyroidism cohort (9.49 vs. 6.03 per 1000 person-years), with an adjusted HR of 1.35 (95% CI 1.18-1.54) after adjusting potential confounders. The incidences of tinnitus, as stratified by gender, age, comorbidity, and follow-up time, were all significantly higher in the hypothyroidism cohort than those in the non-hypothyroidism cohort. The incidence of tinnitus significantly increased with age (aHR = 1.01, 95% CI 1.01-1.02). In conclusion, we report the relationship between hypothyroidism and the increased risk for tinnitus. We also found that hypothyroidism patients are at increased risk of developing tinnitus when associated with comorbidities including vertigo, hearing loss, and insomnia.
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