Evidence map›Paper›PMID 35233033›Full record

SynthesisScientific reports2022

Exploring polygenic contributors to subgroups of comorbid conditions in autism spectrum disorder.

Louis Klein, Shannon D'Urso, Valsamma Eapen, Liang-Dar Hwang, Ping-I Lin

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Louis Klein *School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Shannon D'Urso *Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Valsamma EapenSchool of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Liang-Dar HwangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Ping-I LinSchool of Psychiatry, University of New South Wales, Sydney, NSW, Australia. daniel.lin@unsw.edu.au.
University of Queensland · AUUNSW Sydney · AUSouth Western Sydney Local Health District · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals with autism spectrum disorder (ASD) have heterogeneous comorbid conditions. This study examined whether comorbid conditions in ASD are associated with polygenic risk scores (PRS) of ASD or PRS of comorbid conditions in non-ASD specific populations. Genome-wide single nucleotide polymorphism (SNP) data were obtained from 1386 patients with ASD from the Autism Genetic Resource Exchange (AGRE) study. After excluding individuals with missing clinical information concerning comorbid conditions, a total of 707 patients were included in the study. A total of 18 subgroups of comorbid conditions ('topics') were identified using a machine learning algorithm, topic modeling. PRS for ASD were computed using a genome-wide association meta-analysis of 18,381 cases and 27,969 controls. From these 18 topics, Topic 6 (over-represented by allergies) (p = 1.72 × 10

Indexed as

Autism Spectrum DisorderChronic PainHypersensitivityGenome-Wide Association StudyHumansMultifactorial Inheritance

Identifiers

PMID35233033
PMCPMC8888546
OpenAlexW4220777878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.