Evidence map›Paper›PMID 35233022›Full record

ArticleScientific reports2022

The effect of a variable focal spot size on the contrast channels retrieved in edge-illumination X-ray phase contrast imaging.

A Astolfo, I Buchanan, T Partridge, G K Kallon, C K Hagen, P R T Munro, M Endrizzi, D Bate, A Olivo

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Edge-Illumination X-Ray Dark-Field Tomography.Physical review applied · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

A AstolfoNikon X-Tek Systems Ltd, Tring, Herts, HP23 4JX, UK.
I BuchananDepartment of Medical Physics and Biomedical Engineering, UCL, London, WC1E 6BT, UK.
T PartridgeDepartment of Medical Physics and Biomedical Engineering, UCL, London, WC1E 6BT, UK.
G K KallonDepartment of Medical Physics and Biomedical Engineering, UCL, London, WC1E 6BT, UK.
C K HagenDepartment of Medical Physics and Biomedical Engineering, UCL, London, WC1E 6BT, UK.
P R T MunroDepartment of Medical Physics and Biomedical Engineering, UCL, London, WC1E 6BT, UK.
M EndrizziDepartment of Medical Physics and Biomedical Engineering, UCL, London, WC1E 6BT, UK.
D BateNikon X-Tek Systems Ltd, Tring, Herts, HP23 4JX, UK.
A OlivoDepartment of Medical Physics and Biomedical Engineering, UCL, London, WC1E 6BT, UK. a.olivo@ucl.ac.uk.
University College London · GBNikon (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multi-modal X-ray imaging allows the extraction of phase and dark-field (or "Ultra-small Angle Scatter") images alongside conventional attenuation ones. Recently, scan-based systems using conventional sources that can simultaneously output the above three images on relatively large-size objects have been developed by various groups. One limitation is the need for some degree of spatial coherence, achieved either through the use of microfocal sources, or by placing an absorption grating in front of an extended source. Both these solutions limit the amount of flux available for imaging, with the latter also leading to a more complex setup with additional alignment requirements. Edge-illumination partly overcomes this as it was proven to work with focal spots of up to 100 micron. While high-flux, 100 micron focal spot sources do exist, their comparatively large footprint and high cost can be obstacles to widespread translation. A simple solution consists in placing a single slit in front of a large focal spot source. We used a tunable slit to study the system performance at various effective focal spot sizes, by extracting transmission, phase and dark-field images of the same specimens for a range of slit widths. We show that consistent, repeatable results are obtained for varying X-ray statistics and effective focal spot sizes. As the slit width is increased, the expected reduction in the raw differential phase peaks is observed, compensated for in the retrieval process by a broadened sensitivity function. This leads to the same values being correctly retrieved, but with a slightly larger error bar i.e. a reduction in phase sensitivity. Concurrently, a slight increase in the dark-field signal is also observed.

Indexed as

LightingMicroscopy, Phase-ContrastRadiographyX-Rays

Identifiers

PMID35233022
PMCPMC8888612
OpenAlexW4214640644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.