Evidence map›Paper›PMID 35232960›Full record

ArticleSignal transduction and targeted therapy2022

Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury.

Chen Li, Zhourui Wu, Liqiang Zhou, Jingliang Shao, Xiao Hu, Wei Xu, Yilong Ren, Xingfei Zhu, Weihong Ge, Kunshan Zhang and 10 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 155 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 3 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 3 syntheses or guidelines pooled it, 222 citations in OpenAlex.

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  16. [Mechanisms of Piezo1-mediated microglial ferroptosis in inhibiting spinal cord injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Chen Li *Division of Spine, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Zhourui Wu *Division of Spine, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Liqiang Zhou *Institute of Spinal and Spinal Cord Injury, Tongji University School of Medicine, Shanghai, 200065, China.
Jingliang ShaoInstitute of Spinal and Spinal Cord Injury, Tongji University School of Medicine, Shanghai, 200065, China.
Xiao HuDivision of Spine, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Wei XuDivision of Spine, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Yilong RenDivision of Spine, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Xingfei ZhuKey Laboratory of Spine and Spinal cord Injury Repair and Regeneration (Tongji University), Ministry of Education, Shanghai, 200072, China.
Weihong GeDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Kunshan ZhangInstitute of Spinal and Spinal Cord Injury, Tongji University School of Medicine, Shanghai, 200065, China.
Jiping LiuInstitute of Spinal and Spinal Cord Injury, Tongji University School of Medicine, Shanghai, 200065, China.
Runzhi HuangKey Laboratory of Spine and Spinal cord Injury Repair and Regeneration (Tongji University), Ministry of Education, Shanghai, 200072, China.
Jing YuInstitute of Spinal and Spinal Cord Injury, Tongji University School of Medicine, Shanghai, 200065, China.
Dandan LuoInstitute of Spinal and Spinal Cord Injury, Tongji University School of Medicine, Shanghai, 200065, China.
Xuejiao YangInstitute of Spinal and Spinal Cord Injury, Tongji University School of Medicine, Shanghai, 200065, China.
Wenmin ZhuInstitute of Spinal and Spinal Cord Injury, Tongji University School of Medicine, Shanghai, 200065, China.
Rongrong ZhuKey Laboratory of Spine and Spinal cord Injury Repair and Regeneration (Tongji University), Ministry of Education, Shanghai, 200072, China.
Changhong ZhengInstitute of Spinal and Spinal Cord Injury, Tongji University School of Medicine, Shanghai, 200065, China.
Yi Eve SunKey Laboratory of Spine and Spinal cord Injury Repair and Regeneration (Tongji University), Ministry of Education, Shanghai, 200072, China. yi.eve.sun@gmail.com.
Liming ChengDivision of Spine, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. limingcheng@tongji.edu.cn.
Tongji Hospital · CNTongji University · CNUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) involves diverse injury responses in different cell types in a temporally and spatially specific manner. Here, using single-cell transcriptomic analyses combined with classic anatomical, behavioral, electrophysiological analyses, we report, with single-cell resolution, temporal molecular and cellular changes in crush-injured adult mouse spinal cord. Data revealed pathological changes of 12 different major cell types, three of which infiltrated into the spinal cord at distinct times post-injury. We discovered novel microglia and astrocyte subtypes in the uninjured spinal cord, and their dynamic conversions into additional stage-specific subtypes/states. Most dynamic changes occur at 3-days post-injury and by day-14 the second wave of microglial activation emerged, accompanied with changes in various cell types including neurons, indicative of the second round of attacks. By day-38, major cell types are still substantially deviated from uninjured states, demonstrating prolonged alterations. This study provides a comprehensive mapping of cellular/molecular pathological changes along the temporal axis after SCI, which may facilitate the development of novel therapeutic strategies, including those targeting microglia.

Indexed as

Spinal Cord InjuriesAnimalsAstrocytesMiceMicrogliaNeurons

Identifiers

PMID35232960
PMCPMC8888618
OpenAlexW4214870865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.