ArticleJournal of psychiatry & neuroscience : JPN
Differences in subcortical brain volumes among patients with schizophrenia and bipolar disorder and healthy controls.
Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Five-factor personality traits in patients with schizophrenia and bipolar disorder: a systematic review and meta-analysis.The international journal of neuropsychopharmacology · 2025Pooled it
- Widespread cortical thinning and subcortical alterations in mood and psychotic disorders across first-episode and chronic stages.Journal of affective disorders · 2026Article
- Trans-Tissue Effects of Hippocampus- and Blood-Derived DNA Methylation Risk Scores on Bipolar Disorder Diagnosis.Bipolar disorders · 2026Article
- Associations of polygenic risk scores differentiating attention-deficit hyperactivity disorder from autism spectrum disorder with cognitive and cortical alterations in Schizophrenia patients.European child & adolescent psychiatry · 2025Article
- Mitochondrial genetic variants associated with bipolar disorder and Schizophrenia in a Japanese population.International journal of bipolar disorders · 2023Article
- Sex differences in brainstem structure volumes in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Morphological Abnormalities in Early-Onset Schizophrenia Revealed by Structural Magnetic Resonance Imaging.Biology · 2023Article
- Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders.Nature neuroscience · 2022Article
- Genetic polymorphism and neuroanatomical changes in schizophrenia.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with schizophrenia and bipolar disorder have an overlapping polygenic architecture and clinical similarities, although the 2 disorders are distinct diagnoses with clinical dissimilarities. It remains unclear whether there are specific differences in subcortical volumes between schizophrenia and bipolar disorder, and whether the subcortical differences are affected by any clinical characteristics. We investigated differences in subcortical volumes bilaterally among patients with schizophrenia, patients with bipolar disorder and healthy controls. We also investigated the influences of clinical characteristics on specific subcortical volumes in these patient groups.
methodsWe collected 3 T
resultsOf 7 subcortical regions, patients with schizophrenia had significantly smaller volumes in the left thalamus (Cohen LIMITATIONS: We did not evaluate the differences in subcortical volumes between patients stratified based on clinical bipolar disorder subtype and a history of psychotic episodes because our sample size of patients with bipolar disorder was limited.
conclusionOur findings suggest that volumetric differences in the amygdala between patients with schizophrenia and those with bipolar disorder may be a putative biomarker for distinguishing 2 clinically similar diagnoses.
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