Evidence map›Paper›PMID 35232785›Full record

ArticleBMJ open2022

Prognostic factors for post-traumatic stress, anxiety and depression in women after early pregnancy loss: a multi-centre prospective cohort study.

Jessica Farren, Maria Jalmbrant, Nora Falconieri, Nicola Mitchell-Jones, Shabnam Bobdiwala, Maya Al-Memar, Nina Parker, Ben Van Calster, Dirk Timmerman, Tom Bourne

Abstract readMulticenter Study
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Psychologic Sequelae in Early Pregnancy Complications.International journal of women's health · 2023
    Review
  10. Pregnancy loss: Consequences for mental health.Frontiers in global women's health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jessica FarrenTommy's National Centre for Miscarriage Research, Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.ORCID 0000-0002-8082-6499
Maria JalmbrantTommy's National Centre for Miscarriage Research, Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.ORCID 0000-0001-7587-1140
Nora FalconieriDepartment of Development & Regeneration, KU Leuven, Leuven, Belgium.ORCID 0000-0002-9533-0859
Nicola Mitchell-JonesTommy's National Centre for Miscarriage Research, Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.ORCID 0000-0003-0299-9586
Shabnam BobdiwalaTommy's National Centre for Miscarriage Research, Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.ORCID 0000-0003-0540-2191
Maya Al-MemarTommy's National Centre for Miscarriage Research, Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.ORCID 0000-0002-3662-3010
Nina ParkerTommy's National Centre for Miscarriage Research, Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.ORCID 0000-0002-7962-4451
Ben Van CalsterDepartment of Development & Regeneration, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1613-7450
Dirk TimmermanDepartment of Development & Regeneration, KU Leuven, Leuven, Belgium.ORCID 0000-0002-3707-6645
Tom BourneTommy's National Centre for Miscarriage Research, Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK t.bourne@imperial.ac.uk.ORCID 0000-0003-1421-6059

Funding

Department of Health
6 · The paper itself

Abstract

objectivesTo investigate prognostic factors for anxiety, depression and post-traumatic stress (PTS) symptoms 1 month after early pregnancy loss (EPL).

designA prospective cohort study. Consecutive women were recruited, and demographic and clinical data were collected. Surveys containing the Hospital Anxiety and Depression Scale (HADS) and Post-traumatic Stress Diagnostic Scale (PDS) were emailed 1 month after a loss. Univariable logistic regression was performed to link factors with caseness of anxiety, depression or PTS according to screening measures.

settingEarly pregnancy units of three central London hospitals.

participants737/1116 eligible women with an EPL were recruited. 492 responded to HADS and 487 to PDS. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome is the area under the curve (AUC) to predict any psychological morbidity (defined as moderate/severe anxiety or depression, or meeting screening criteria for PTS) for each variable. Further outcomes are explained variation (R

resultsWomen who had a past diagnosis of a psychiatric condition were more likely to meet criteria for anxiety, depression or PTS (75% for current diagnosis vs 55% for past vs 30% for no diagnosis; AUC 0.61; R

conclusionsWomen with a history of mental health problems, or those with previous losses, may be at higher risk of psychological illness 1 month after pregnancy loss. However, prognostic ability was poor overall. All women should be considered at risk.

Indexed as

Abortion, SpontaneousStress Disorders, Post-TraumaticAnxietyChildDepressionFemaleHumansPregnancyPrognosisProspective StudiesStress, Psychologicalanxiety disordersdepression & mood disordersreproductive medicine

Identifiers

PMID35232785
PMCPMC8889314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.