ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Thalamocortical Mechanisms for Nostalgia-Induced Analgesia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The Human Dorsolateral Prefrontal Cortex in Pain and Pain Modulation: A Review and Activation-Likelihood Estimation Approach.European journal of pain (London, England) · 2026Pooled it
- Nostalgia and Envisioning Reduce Pain Ratings in Healthy Adults and Individuals With Chronic Pain.European journal of pain (London, England) · 2026Article
- Music-Evoked Nostalgia Activates Default Mode and Reward Networks Across the Lifespan.Human brain mapping · 2025Article
- Recent Advances in Multimodal Non-Pharmacological Interventions for Late-Life Depression.Neuropsychiatric disease and treatment · 2025Review
- Electroacupuncture Alleviates Hyperalgesia and Anxiety-Like Behaviors in Pain Memory Model Rats Through Activation of GABAergic Neurons and GABA Receptor in the Rostral Anterior Cingulate Cortex.Molecular neurobiology · 2024Article
- The dual facilitatory and inhibitory effects of social pain on physical pain perception.iScience · 2024Article
- Neural circuit mechanisms of acupuncture effect: where are we now?Frontiers in neurology · 2024Review
- The causal relationship between human brain morphometry and knee osteoarthritis: a two-sample Mendelian randomization study.Frontiers in genetics · 2024Article
- A Manifesto in Defense of Pain Complexity: A Critical Review of Essential Insights in Pain Neuroscience.Journal of clinical medicine · 2023Review
- Structural and Physiological Modeling (SAPM) for the Analysis of Functional MRI Data Applied to a Study of Human Nociceptive Processing.Brain sciences · 2023Article
- Disrupting nociceptive information processing flow through transcranial focused ultrasound neuromodulation of thalamic nuclei.Brain stimulationArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a predominately positive emotion, nostalgia serves various adaptive functions, including a recently revealed analgesic effect. The current fMRI study aimed to explore the neural mechanisms underlying the nostalgia-induced analgesic effect on noxious thermal stimuli of different intensities. Human participants' (males and females) behavior results showed that the nostalgia paradigm significantly reduced participants' perception of pain, particularly at low pain intensities. fMRI analysis revealed that analgesia was related to decreased brain activity in pain-related brain regions, including the lingual and parahippocampal gyrus. Notably, anterior thalamic activation during the nostalgia stage predicted posterior parietal thalamus activation during the pain stage, suggesting that the thalamus might play a key role as a central functional linkage in the analgesic effect. Moreover, while thalamus-PAG functional connectivity was found to be related to nostalgic strength, periaqueductal gray-dorsolateral prefrontal cortex (PAG-dlPFC) functional connectivity was found to be associated with pain perception, suggesting possible analgesic modulatory pathways. These findings demonstrate the analgesic effect of nostalgia and, more importantly, shed light on its neural mechanism.
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Registered trials
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