ArticleBMC veterinary research2022
Outbreak of neuropathogenic equid herpesvirus 1 causing abortions in Yili horses of Zhaosu, North Xinjiang, China.
Article in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.Pathogens (Basel, Switzerland) · 2025Article
- Equine Herpesvirus Infections: Treatment Progress and Challenges in Horses and Donkeys.Veterinary sciences · 2025Review
- A multiplex real-time PCR assay for detection of equid herpesvirus 1 and 4.Scientific reports · 2025Article
- Genomic analysis and replication kinetics of the closely related EHV-1 neuropathogenic 21P40 and abortigenic 97P70 strains.Veterinary research · 2025Article
- Spatial Modeling of Equine Herpesviruses 1 (EHVs-1) Risks in Kazakhstan Using 2017-2024 Surveillance Data.Transboundary and emerging diseases · 2025Article
- Detection of equine herpesvirus antibodies in large-scale donkey farms in Liaocheng area.Veterinary medicine and science · 2024Article
- Evaluation of Non-Invasive Sampling Techniques for the Molecular Surveillance of Equid Herpesviruses in Yearling Horses.Viruses · 2024Article
- An Overview of Infectious and Non-Infectious Causes of Pregnancy Losses in Equine.Animals : an open access journal from MDPI · 2024Review
- First identification and isolation of equine herpesvirus type 1 in aborted fetal lung tissues of donkeys.Virology journal · 2024Article
- Identification of neuropathogenic Varicellovirus equidalpha1 as a potential cause of respiratory disease outbreaks among horses in North Xinjiang, China, from 2021-2023.BMC veterinary research · 2024Article
- Abortion storm of Yili horses is associated with Equus caballus papillomavirus 2 variant infection.Archives of microbiology · 2023Article
- Equine abortion and stillbirth in California: a review of 1,774 cases received at a diagnostic laboratory, 1990-2022.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEHV-1 is one of the most serious viral pathogens that frequently cause abortion in horses around the world. However, so far, relatively little information is available on EHV-1 infections as they occur in China. In January 2021, during an abortion storm which occurred in Yili horses at the Chinese State Studs of Zhaosu (North Xinjiang, China), 43 out of 800 pregnant mares aborted.
resultsPCR detection revealed the presence of EHV-1 in all samples as the possible cause of all abortions, although EHV-4, EHV-2 and EHV-5 were also found to circulate in the aborted fetuses. Furthermore, the partial ORF33 sequences of the 43 EHV-1 shared 99.3-100% and 99.0-100% similarity in nucleotide and amino acid sequences respectively. These sequences not only indicated a highly conserved region but also allowed the strains to group into six clusters. In addition, based on the predicted ORF30 nucleotide sequence, it was found that all the strains carried a guanine at the 2254 nucleotide position (aspartic acid at position 752 of the viral DNA polymerase) and were, therefore, identified as neuropathogenic strains.
conclusionThis study is the first one that establishes EHV-1 as the cause of abortions in Yili horses, of China. Further characterization of the ORF30 sequences revealed that all the EHV-1 strains from the study carried the neuropathogenic genotype. Totally, neuropathogenic EHV-1 infection in China's horse population should be concerned although the virus only detected in Yili horse abortions.
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