Observational studyBMC pregnancy and childbirth2022
Adherence to treatment for hypothyroidism in pregnancy and relationship with thyrotropin control: a retrospective observational cohort study.
Observational study in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Preconception thyroid function optimization and pregnancy outcomes in women with recurrent pregnancy loss: a real-world cohort study.Endocrine connections · 2026Article
- Article
- Evaluation of the Risk of Adverse Maternal and Neonatal Outcomes Among Immigrant and Native-Born Women: A Retrospective Observational Analysis.Health science reports · 2025Article
- Subtypes of hypertension and their association to comorbidities and ethnicity in pregnant women.PloS one · 2025Observational
- Hypertension subtypes and adverse maternal and perinatal outcomes - a retrospective population-based cohort study.BMC pregnancy and childbirth · 2024Article
- Maternal and foetal complications of pregestational and gestational diabetes: a descriptive, retrospective cohort study.Scientific reports · 2024Article
- Obesity in Pregnancy as a Risk Factor in Maternal and Child Health-A Retrospective Cohort Study.Metabolites · 2024Article
- Levothyroxine Treatment Among Pregnant Women and Risk of Seizure in Children: A Population-Based Cohort Study.Drug safety · 2023Article
- Levothyroxine: Conventional and Novel Drug Delivery Formulations.Endocrine reviews · 2023Review
- Ethnic Disparities and Obesity Risk Factors in Pregnant Women: A Retrospective Observational Cohort Study.Nutrients · 2023Observational
- Prevalence, risk factors, and consequences of hypothyroidism among pregnant women in the health region of Lleida: A cohort study.PloS one · 2023Observational
- Compliance with Medications Among Saudi Pregnant Women with Diabetes: Insights from a Large Tertiary Hospital, Riyadh, Saudi Arabia.Inquiry : a journal of medical care organization, provision and financingArticle
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHypothyroidism is the second most common endocrinological disease during pregnancy, with percentages that can range between 3.2 and 5.5%. A good maternal and foetal health outcome depends on thyroid hormone replacement therapy. The goal of such therapy is to maintain thyrotropin (TSH) in a range that is specific for pregnant women and varies between the trimesters of pregnancy. In our study, we wanted to analyse the adherence to hypothyroidism treatment among pregnant women and to evaluate the degree of control of the disease.
methodsWe performed a retrospective observational cohort study in pregnant women between 2012 and 2018 in the Lleida health region. Therapeutic adherence was analysed by the proportion of days covered (PDC). The relationship with other variables was assessed using the regression coefficients and their 95% confidence interval (CI).
resultsWe examined a sample of 17,281 women, representing more than 92% of the pregnant women in the Lleida health region in the period analysed. Among this sample, the mean prevalence of hypothyroidism was 6.52% (0.07% clinical and 6.45% subclinical). 3.3% of the 17,281 pregnant women were treated. Among them, the mean adherence score was 79.6 ± 22.2. Of these, 54% presented high adherence. The latter had a higher mean age and better TSH control, in comparison to the ones showing low adherence.
conclusionsHalf of the treated patients had good adherence to treatment and a better TSH control, in comparison to the others. Most of them achieved a good control at the third trimester of pregnancy.
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