Evidence map›Paper›PMID 35232252›Full record

ArticleOpen biology2022

Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system.

Vaishaali Natarajan, Camille R Simoneau, Ann L Erickson, Nathan L Meyers, Jody L Baron, Stewart Cooper, Todd C McDevitt, Melanie Ott

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
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  4. [Advances in the construction and application of a novel liver organoid model for hepatitis B virus infection].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
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  12. Coculture of tumor organoids with pathogenic microorganisms: a novel system to mimicFrontiers in cellular and infection microbiology · 2025
    Review
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  15. FromLab on a chip · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Vaishaali NatarajanThe Gladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-3668-2803
Camille R SimoneauThe Gladstone Institutes, San Francisco, CA, USA.ORCID 0000-0001-9222-8130
Ann L EricksonDivision of General and Transplant Hepatology, California Pacific Medical Center and Research Institute, San Francisco, CA, USA.
Nathan L MeyersThe Gladstone Institutes, San Francisco, CA, USA.ORCID 0000-0001-5983-3777
Jody L BaronUCSF Liver Center, University of California San Francisco, San Francisco, CA, USA.
Stewart CooperDivision of General and Transplant Hepatology, California Pacific Medical Center and Research Institute, San Francisco, CA, USA.
Todd C McDevittThe Gladstone Institutes, San Francisco, CA, USA.
Melanie OttThe Gladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-5697-1274
Gladstone Institutes · USUniversity of California, San Francisco · USCalifornia Pacific Medical Center · US

Funding

A new model of accelerated immune aging in HIV-infected drug usersDP1DA038043 · NIDA · J. DAVID GLADSTONE INSTITUTES · PI OTT, MELANIE MARIA · 2014 to 2019
$4.8M
Role of Lipid Droplets in Hepatitis C Virus InfectionR01AI097552 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI OTT, MELANIE MARIA · 2014 to 2018
$2.4M
The Melanocortin-4 Receptor in Human ObesityR01DK064051 · NIDDK · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI COOPER, STEWART · 2003 to 2007
$1.8M
NIAID NIH HHS R01 AI097552NIDA NIH HHS DP1 DA038043NIDDK NIH HHS R01 DK064051
6 · The paper itself

Abstract

Hepatitis C virus (HCV) remains a global public health challenge with an estimated 71 million people chronically infected, with surges in new cases and no effective vaccine. New methods are needed to study the human immune response to HCV since

Indexed as

CD8-Positive T-LymphocytesHepatitis COrganoidsCoculture TechniquesHepacivirusHumansMicrofluidicsViral Nonstructural ProteinsViral Nonstructural ProteinsCD8+ T cellshepatitis Cliver organoidmicrofluidics

Identifiers

PMID35232252
PMCPMC8889170
OpenAlexW4214908128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.