ArticleProceedings. Biological sciences2022
Experimental demonstration of prenatal programming of mitochondrial aerobic metabolism lasting until adulthood.
Article in Proceedings. Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Incubation temperature shapes growth and mitochondrial metabolism across embryonic development in Japanese quail.Proceedings. Biological sciences · 2025Article
- Linking performance to powerhouse: mitochondrial aerobic metabolism in blood cells reflects flight endurance of house sparrows (Biology letters · 2025Article
- Prenatal conditions do not affect brain physiology and learning in a lizard.The Journal of experimental biology · 2025Article
- Postnatal development in the cold render bird mitochondria more susceptible to heat stress.Proceedings. Biological sciences · 2025Article
- Article
- From eggs to adulthood: sustained effects of early developmental temperature and corticosterone exposure on physiology and body size in an Australian lizard.The Journal of experimental biology · 2024Article
- High-temperature exposure during the early embryonic stage lowers core body temperature after growth via a hypothalamic Igfbp2-dependent mechanism.Scientific reports · 2024Article
- How important is hidden phenotypic plasticity arising from alternative but converging developmental trajectories, and what limits it?The Journal of experimental biology · 2024Article
- The relationship between mitochondrial respiration, resting metabolic rate and blood cell count in great tits.Biology open · 2024Article
- Non-lethal sampling for assessment of mitochondrial function does not affect metabolic rate and swimming performance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- An evolving roadmap: using mitochondrial physiology to help guide conservation efforts.Conservation physiology · 2024Article
- Mitochondrial function declines with age within individuals but is not linked to the pattern of growth or mortality risk in zebra finch.Aging cell · 2023Article
- Plasticity of mitochondrial function safeguards phosphorylating respiration during in vitro simulation of rest-phase hypothermia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Short- and long-term consequences of heat exposure on mitochondrial metabolism in zebra finches (Taeniopygia castanotis).Oecologia · 2023Article
- Effect of prenatal glucocorticoids and thyroid hormones on developmental plasticity of mitochondrial aerobic metabolism, growth and survival: an experimental test in wild great tits.The Journal of experimental biology · 2022Article
- Experimental demonstration of prenatal programming of mitochondrial aerobic metabolism lasting until adulthood.Proceedings. Biological sciences · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is increasingly being postulated that among-individual variation in mitochondrial function underlies variation in individual performance (e.g. growth rate) and state of health. It has been suggested (but not adequately tested) that environmental conditions experienced before birth could programme postnatal mitochondrial function, with persistent effects potentially lasting into adulthood. We tested this hypothesis in an avian model by experimentally manipulating prenatal conditions (incubation temperature and stability) and then measuring mitochondrial aerobic metabolism in blood cells from the same individuals during the middle of the growth period and at adulthood. Mitochondrial aerobic metabolism changed markedly across life stages, and parts of these age-related changes were influenced by the prenatal temperature conditions. A high incubation temperature induced a consistent and long-lasting increase in mitochondrial aerobic metabolism. Postnatal mitochondrial aerobic metabolism was positively associated with oxidative damage on DNA but not telomere length. While we detected significant within-individual consistency in mitochondrial aerobic metabolism across life stages, the prenatal temperature regime only accounted for a relatively small proportion (less than 20%) of the consistent among-individual differences we observed. Our results demonstrate that prenatal conditions can programme consistent and long-lasting differences in mitochondrial function, which could potentially underlie among-individual variation in performance and health state.
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