ArticleCerebral cortex (New York, N.Y. : 1991)2022
Age differences in the functional architecture of the human brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Meta-analytic evidence for distinct neural correlates of conditioned versus verbally induced placebo analgesia.Nature communications · 2026Pooled it
- Population-Level Age Effects on the White Matter Structure Subserving Cognitive Flexibility in the Human Brain.eNeuro · 2026Pooled it
- Functional gradient analysis reveals potential therapeutic mechanisms of nrTMS for postoperative motor deficits in glioma patients: A randomized controlled trial.NeuroImage. Clinical · 2026Trial
- Hierarchical disruption of lateral prefrontal cortex gradients in cognitive aging.GeroScience · 2026Article
- Diurnal dynamics of multilayer brain networks predict cognitive trajectories in aging.GeroScience · 2026Article
- Regional Brain Volume Variation Across Adulthood: A Cross-Sectional MRI Analysis of Age, Sex, and Hemispheric Asymmetry.Life (Basel, Switzerland) · 2026Article
- Article
- Blunted modulation of hierarchical brain organization in opioid use disorder.Research square · 2026Article
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- Individualized Mapping of Functional Brain Networks in Older Adulthood.bioRxiv : the preprint server for biology · 2026Article
- The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization.Nature communications · 2026Article
- High brain network system segregation is differentially linked with cognitive performance across the life span.Network neuroscience (Cambridge, Mass.) · 2026Article
- Functional differentiation of the default and frontoparietal control networks predicts individual differences in creative achievement: evidence from macroscale cortical gradients.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.Neurobiology of aging · 2025Review
- Analysis of functional connectivity changes from childhood to old age: A study using HCP-D, HCP-YA, and HCP-A datasets.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity.Scientific reports · 2025Article
- Characterizing changes to individual-specific brain signature with age.Frontiers in aging neuroscience · 2025Article
- Editorial: Neuroimaging of the aging brain.Frontiers in neuroimaging · 2025Article
- Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neural correlates of reduced sensitivity to information about uncertainty during valuation in older adults: An fNIRS study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
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Authors and funding
21 authors at 11 institutions in 5 countries.
Funding
Abstract
The intrinsic functional organization of the brain changes into older adulthood. Age differences are observed at multiple spatial scales, from global reductions in modularity and segregation of distributed brain systems, to network-specific patterns of dedifferentiation. Whether dedifferentiation reflects an inevitable, global shift in brain function with age, circumscribed, experience-dependent changes, or both, is uncertain. We employed a multimethod strategy to interrogate dedifferentiation at multiple spatial scales. Multi-echo (ME) resting-state fMRI was collected in younger (n = 181) and older (n = 120) healthy adults. Cortical parcellation sensitive to individual variation was implemented for precision functional mapping of each participant while preserving group-level parcel and network labels. ME-fMRI processing and gradient mapping identified global and macroscale network differences. Multivariate functional connectivity methods tested for microscale, edge-level differences. Older adults had lower BOLD signal dimensionality, consistent with global network dedifferentiation. Gradients were largely age-invariant. Edge-level analyses revealed discrete, network-specific dedifferentiation patterns in older adults. Visual and somatosensory regions were more integrated within the functional connectome; default and frontoparietal control network regions showed greater connectivity; and the dorsal attention network was more integrated with heteromodal regions. These findings highlight the importance of multiscale, multimethod approaches to characterize the architecture of functional brain aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.