ArticleOral oncology2022
The impact of head and neck radiotherapy on salivary flow and quality of life: Results of the ORARAD study.
Article in Oral oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02057510 (Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients
Who cites it
18 citing papers in PubMed.
- Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial.Brazilian oral research · 2025Trial
- Updating the standard model of care for oropharyngeal cancers-are we there yet?Translational cancer research · 2026Article
- Photobiomodulation for salivary gland dysfunction: aligning clinical expectations with etiology-dependent treatment responsiveness.Lasers in medical science · 2026Review
- Influencing factors of oral frailty in elderly patients with head and neck cancer: a multicenter, cross-sectional study.BMC oral health · 2026Observational
- The impact of medications on salivary flow and oral health-related quality of life in postradiation head and neck cancer patients: results of the OraRad study.Oral surgery, oral medicine, oral pathology and oral radiology · 2025Article
- The Importance of Dental Treatment in Patients Before Radiotherapy, Chemotherapy, and Cardiac Surgeries: A Narrative Review.Journal of clinical medicine · 2025Review
- Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer.Oral diseases · 2025Observational
- Article
- Effects of photobiomodulation and bethanechol chloride treatment on salivary composition and flow rate in head and neck cancer patients undergoing radiotherapy: longitudinal interventional experimental clinical study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Current basic and preclinical research for treatment of radiation therapy-induced hyposalivation.JADA foundational science · 2025Article
- Explorative study of stimulated saliva proteome in head and neck cancer patients pre- and post-treatment.Heliyon · 2024Article
- The impact of submandibular glands protection on xerostomia as monitored by diffusion-weighted imaging in nasopharyngeal carcinoma patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Article
- Factors associated with oral hygiene compliance in patients treated with radiation therapy for head and neck cancer.Journal of the American Dental Association (1939) · 2024Observational
- Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning.Scientific reports · 2024Article
- Tooth-level predictors of tooth loss and exposed bone after radiation therapy for head and neck cancer.Journal of the American Dental Association (1939) · 2023Observational
- Oral health-related quality of life after radiation therapy for head and neck cancer: the OraRad study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Observational
- Clinical parameters predictors of malignant transformation of recurrent parotid pleomorphic adenoma.Scientific reports · 2023Article
- Adaptive Volumetric-Modulated Arc Radiation Therapy for Head and Neck Cancer: Evaluation of Benefit on Target Coverage and Sparing of Organs at Risk.Current oncology (Toronto, Ont.) · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectivesSalivary hypofunction and xerostomia, are common side effects of radiotherapy, negatively impacting quality of life. The OraRad study presents results on the longitudinal impact of radiotherapy on salivary flow and patient-reported outcomes. PATIENTS AND
methodsProspective, multicenter cohort study of 572 patients receiving curative-intent head and neck radiotherapy (RT). Stimulated salivary flow (SSF) rate and patient-reported outcomes were measured prior to RT and at 6- and 18-months post-RT. Linear mixed effects models examined the relationship between RT dose and change in salivary flow, and change in patient-reported outcomes.
results544 patients had baseline salivary flow measurement, with median (IQR) stimulated flow rate of 0.975 (0.648, 1.417) g/min. Average RT dose to parotid glands was associated with change in salivary flow post-RT (p < 0.001). Diminished flow to 37% of pre-RT level was observed at 6 months (median: 0.358, IQR: 0.188 to 0.640 g/min, n = 481) with partial recovery to 59% of pre-RT at 18 months (median: 0.575, IQR: 0.338 to 0.884 g/min, n = 422). Significant improvement in patient-reported swallowing, senses (taste and smell), mouth opening, dry mouth, and sticky saliva (p-values < 0.03) were observed between 6 and 18 months post-RT. Changes in swallowing, mouth opening, dry mouth, and sticky saliva were significantly associated with changes in salivary flow from baseline (p-values < 0.04).
conclusionSalivary flow and patient-reported outcomes decreased as a result of RT, but demonstrated partial recovery during follow-up. Continued efforts are needed to improve post-RT salivary function to support quality of life.
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Registered trials
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