Observational studyPLoS neglected tropical diseases2022
Factors associated with in-hospital mortality of adult tetanus patients-a multicenter study from Bangladesh.
Observational study in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mortality and risk factors in hospitalised adult patients with tetanus: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Non-Neonatal Tetanus in Mogadishu, Somalia: Clinical Characteristics, Management, and Outcomes-First Report from a Tetanus Referral Centre.Tropical medicine and infectious disease · 2026Article
- Article
- Mortality and Associated Factors Among Adult Tetanus Patients Admitted at Public Hospitals in Bahir Dar City, Ethiopia: A Cross-Sectional Study.Health science reports · 2026Article
- Analysis of 92 hospitalized cases of non-neonatal tetanus in Guizhou Province, China.Frontiers in public health · 2026Article
- Management and outcome of adult generalized tetanus patients in a tertiary hospital in Anhui, China: a retrospective study.Frontiers in public health · 2026Article
- Factors Influencing the Length of Emergency Intensive Care Unit Stay in Adult Tetanus Patients.International journal of general medicine · 2025Article
- A study of association between maternal tetanus toxoid immunization and neonatal mortality in the context of Bangladesh.PloS one · 2025Article
- An Unexpected Case of Generalized Tetanus.Cureus · 2024Article
- Management and outcome of adult generalized tetanus in a Chinese tertiary hospital.Frontiers in public health · 2024Observational
- Trends and Hospitalization Outcomes of Tetanus Cases: A Multicenter Retrospective Study in Suzhou, 2013-2023.Risk management and healthcare policy · 2024Article
- Case Report: A Challenging Case of Tetanus Presenting with Headache.The American journal of tropical medicine and hygiene · 2023Article
- Generalized tetanus in a farmer following treatment of an open ankle fracture by a traditional bone setter.Clinical case reports · 2023Article
- Adult tetanus is not gone yet, but could be ready to leave: A case-series from central India.Germs · 2023Article
- Tetanus in Uganda: Clinical Outcomes of Adult Patients Hospitalized at a Tertiary Health Facility Between 2011 and 2020.Open forum infectious diseases · 2022Article
- Tetanus secondary to oral and odontogenic infections: a case report and systematic literature review.Le infezioni in medicina · 2022Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTetanus, a vaccine-preventable disease, is still occurring in the elderly population of low- and middle-income countries with a high case-fatality rate. The objective of the study was to elucidate the factors associated with in-hospital mortality of tetanus in Bangladesh.
methodsThis prospective observational study, conducted in two specialized infectious disease hospitals, conveniently selected adult tetanus patients (≥18 years) for inclusion. Data were collected through a preformed structured questionnaire. Kaplan Meier survival analysis and univariate and multivariable Cox regression analysis were carried out to assess factors associated with in-hospital mortality among patients. All analysis was done using Stata (version 16) and SPSS (version 26).
resultsA total of 61 tetanus cases were included, and the overall in-hospital mortality rate was 34.4% (n = 21). Patients had an average age of 46.49 ±15.65 years (SD), and the majority were male (96.7%), farmers (57.4%), and came from rural areas (93.4%). Survival analysis revealed that the probability of death was significantly higher among patients having an age of ≥ 40 years, incubation time of ≤12 days, onset time of ≤ 4 days, and having complication(s). However, on multivariable Cox regression analysis, age (adjusted hazard ratio [aHR] 4.03, 95% Confidence Interval [CI] 1.07-15.17, p = 0.039) and onset time (≤4 days) (aHR 3.33; 95% CI 1.05-10.57, p = 0.041) came as significant predictors of in-hospital mortality after adjusting for incubation period and complications.
conclusionOlder age and short onset time are the two most important determinants of in-hospital mortality of tetanus patients. Hence, these patients require enhanced emphasis and care.
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