Evidence map›Paper›PMID 35230971›Full record

ArticleAging2022

Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B.

Deepak Kumar, Manoj K Kashyap, Zhe Yu, Ide Spaanderman, Reymundo Villa, Thomas J Kipps, James J La Clair, Michael D Burkart, Januario E Castro

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Deepak KumarMoores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Manoj K KashyapMoores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Zhe YuMoores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Ide SpaandermanMoores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Reymundo VillaDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
Thomas J KippsMoores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
James J La ClairDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
Michael D BurkartDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
Januario E CastroMoores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
University of California, San Diego · US

Funding

Tissue CoreP01CA081534 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KIPPS, THOMAS J · 2000 to 2016
$59.5M
NCI NIH HHS P01 CA081534
6 · The paper itself

Abstract

Alterations in RNA splicing are associated with different malignancies, including leukemia, lymphoma, and solid tumors. The RNA splicing modulators such as FD-895 and pladienolide B have been investigated in different malignancies to target/modulate spliceosome for therapeutic purpose. Different cell lines were screened using an RNA splicing modulator to test

Indexed as

RNA SplicingWnt Signaling PathwayEpoxy CompoundsHeLa CellsHumansMacrolidesRNA, MessengerEpoxy CompoundsFD 895Macrolidespladienolide BRNA, MessengerFD-895intron retentionpladienolide Bsplice modulationspliceosomesplicingWnt signaling

Identifiers

PMID35230971
PMCPMC8954975
OpenAlexW4214734116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.