Evidence map›Paper›PMID 35230889›Full record

ReviewGut microbes

The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases.

Rohma Ghani, Benjamin H Mullish, Lauren A Roberts, Frances J Davies, Julian R Marchesi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  11. Antibiotic perturbations to the gut microbiome.Nature reviews. Microbiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rohma GhaniDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Benjamin H MullishDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0001-6300-3100
Lauren A RobertsDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Frances J DaviesMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK.
Julian R MarchesiDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-7994-5239

Funding

Medical Research Council MR/R000875/1Medical Research Council MR/T005254/1
6 · The paper itself

Abstract

The intestinal microbiota is recognized to play a role in the defense against infection, but conversely also acts as a reservoir for potentially pathogenic organisms. Disruption to the microbiome can increase the risk of invasive infection from these organisms; therefore, strategies to restore the composition of the gut microbiota are a potential strategy of key interest to mitigate this risk. Fecal (or Intestinal) Microbiota Transplantation (FMT/IMT), is the administration of minimally manipulated screened healthy donor stool to an affected recipient, and remains the major 'whole microbiome' therapeutic approach at present. Driven by the marked success of using FMT in the treatment of recurrent

Indexed as

Clostridioides difficileClostridium InfectionsCommunicable DiseasesGastrointestinal MicrobiomeMicrobiotaFecal Microbiota TransplantationFecesHumansTreatment Outcomeantibiotic resistancefecal microbiota transplantationFMTgut microbiotaIMTinfectious diseasesintestinal microbiotaIntestinal microbiota transplantation

Identifiers

PMID35230889
PMCPMC8890388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.