Evidence map›Paper›PMID 35230826›Full record

ArticleACS nano2022

Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury.

Kurt Bachmaier, Andrew Stuart, Abhalaxmi Singh, Amitabha Mukhopadhyay, Sreeparna Chakraborty, Zhigang Hong, Li Wang, Yoshikazu Tsukasaki, Mark Maienschein-Cline, Balaji B Ganesh and 3 more

Open access · hybridAbstract read
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Alveolar macrophage-neutrophil crosstalk in acute lung injury: mechanisms, feedback loops, and therapeutic opportunities.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  12. Albumin Nanoparticle-Based Drug Delivery Systems.International journal of nanomedicine · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Neutrophil sub-types in maintaining immune homeostasis during steady state, infections and sterile inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kurt BachmaierDepartment of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, E403, 835 South Wolcott Avenue, Chicago, Illinois 60612, United States.
Andrew StuartNano Biotherapeutics, Inc., 2201 West Campbell Park Drive, Chicago, Illinois 60612, United States.
Abhalaxmi SinghDepartment of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, E403, 835 South Wolcott Avenue, Chicago, Illinois 60612, United States.
Amitabha MukhopadhyayDepartment of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, E403, 835 South Wolcott Avenue, Chicago, Illinois 60612, United States.
Sreeparna ChakrabortyDepartment of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, E403, 835 South Wolcott Avenue, Chicago, Illinois 60612, United States.
Zhigang HongDepartment of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, E403, 835 South Wolcott Avenue, Chicago, Illinois 60612, United States.
Li WangDepartment of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, E403, 835 South Wolcott Avenue, Chicago, Illinois 60612, United States.
Yoshikazu TsukasakiDepartment of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, E403, 835 South Wolcott Avenue, Chicago, Illinois 60612, United States.
Mark Maienschein-ClineResearch Resources Center, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Balaji B GaneshResearch Resources Center, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Prasad KantetiNano Biotherapeutics, Inc., 2201 West Campbell Park Drive, Chicago, Illinois 60612, United States.
Jalees RehmanDepartment of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, E403, 835 South Wolcott Avenue, Chicago, Illinois 60612, United States.
Asrar B MalikDepartment of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, E403, 835 South Wolcott Avenue, Chicago, Illinois 60612, United States.ORCID 0000-0002-8205-7128
University of Illinois Urbana-Champaign · USNanotherapeutics (United States) · USUniversity of Illinois Chicago · US

Funding

TRAINING PROGRAM IN LUNG BIOLOGY AND PATHOBIOLOGYT32HL007829 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 1995 to 2026
$15.6M
Mechanisms and Treatment of SARS-CoV-2 induced Lung Endothelial InjuryR01HL162308 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES, RICHNER, JUSTIN · 2022 to 2025
$2.9M
Albumin Nanoparticles Incorporating Piceatannol (PANPs) for ALI/ARDS therapyR42HL126456 · NHLBI · NANO BIOTHERAPEUTICS, INC. · PI KANTETI, PRASAD V. S., MALIK, ASRAR B. · 2017 to 2019
$2.7M
Nanoparticle Targeting of Neutrophil Subpopulations in Inflammatory Lung InjuryR01HL149300 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B., REHMAN, JALEES · 2019 to 2022
$2.4M
HLS13-13 Albumin nanoparticle based technology to treat ARDSR41HL126456 · NHLBI · CELL BIOLOGICS, INC. · PI BACHMAIER, KURT · 2015 to 2016
$688k
Cblb-based Drugs Against Sepsis and InflammationR41HL118896 · NHLBI · CELL BIOLOGICS, INC. · PI BACHMAIER, KURT, GAO, XIAO-PEI · 2014 to 2014
$219k
NHLBI NIH HHS R01 HL149300NHLBI NIH HHS R01 HL162308NHLBI NIH HHS R41 HL118896NHLBI NIH HHS R41 HL126456NHLBI NIH HHS R42 HL126456NHLBI NIH HHS T32 HL007829
6 · The paper itself

Abstract

The complex involvement of neutrophils in inflammatory diseases makes them intriguing but challenging targets for therapeutic intervention. Here, we tested the hypothesis that varying endocytosis capacities would delineate functionally distinct neutrophil subpopulations that could be specifically targeted for therapeutic purposes. By using uniformly sized (∼120 nm in diameter) albumin nanoparticles (ANP) to characterize mouse neutrophils

Indexed as

NanoparticlesNeutrophilsAlbuminsAnimalsEndocytosisInflammationMiceAlbuminsbacterial infectionchemokine receptorsdrug carriersinflammationnanotechnologynanotherapeuticsneutrophil heterogeneity

Identifiers

PMID35230826
PMCPMC8945372
OpenAlexW4214641830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.