ArticleAccounts of chemical research2022
Advancing Chelation Strategies for Large Metal Ions for Nuclear Medicine Applications.
Article in Accounts of chemical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Radiolabeled Iron-Based Nanomaterials for Cancer Diagnosis and Therapy.International journal of nanomedicine · 2026Review
- Preclinical characterization of 3p-C-DEPAEJNMMI radiopharmacy and chemistry · 2025Article
- Research progress on nanotoxicity and detoxification of cobalt in metal-based implants.Annals of medicine · 2025Review
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- Radiolabeled Nanogels: From Multimodality Imaging to Combination Therapy of Cancer.Small science · 2025Review
- 18-membered macrocycle appended on resin for selective rare earth element extraction and separation.Communications chemistry · 2025Article
- The Advancement of Targeted Alpha Therapy and the Role of Click Chemistry Therein.Molecules (Basel, Switzerland) · 2025Review
- Crystal structure of di-μ-acetato-κActa crystallographica. Section E, Crystallographic communications · 2025Article
- Assembling a new generation of radiopharmaceuticals with supramolecular theranostics.Nature reviews. Chemistry · 2024Review
- Biogeochemistry of Actinides: Recent Progress and Perspective.ACS environmental Au · 2024Review
- Force Fields, Quantum-Mechanical- and Molecular-Dynamics-Based Descriptors of Radiometal-Chelator Complexes.Molecules (Basel, Switzerland) · 2024Article
- Chelation of [Dalton transactions (Cambridge, England : 2003) · 2024Article
- PYTA: a universal chelator for advancing the theranostic palette of nuclear medicine.Chemical science · 2024Article
- Recent advances and impending challenges for the radiopharmaceutical sciences in oncology.The Lancet. Oncology · 2024Review
- Approaches to Reducing Normal Tissue Radiation from Radiolabeled Antibodies.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Tumor targeted alpha particle therapy with an actinium-225 labelled antibody for carbonic anhydrase IX.Chemical science · 2024Article
- Structure and bonding of a radium coordination compound in the solid state.Nature chemistry · 2024Article
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2 authors.
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Abstract
Nuclear medicine leverages radioisotopes of a wide range of elements, a significant portion of which are metals, for the diagnosis and treatment of disease. To optimally use radioisotopes of the metal ions, or radiometals, for these applications, a chelator that efficiently forms thermodynamically and kinetically stable complexes with them is required. The chelator also needs to attach to a biological targeting vector that locates pathological tissues. Numerous chelators suitable for small radiometals have been established to date, but chelators that work well for large radiometals are significantly less common. In this Account, we describe recent progress by us and others in the advancement of ligands for large radiometal chelation with emerging applications in nuclear medicine.First, we discuss and analyze the coordination chemistry of the chelator macropa, a macrocyclic ligand that contains the 18-crown-6 backbone and two picolinate pendent arms, with large metal ions in the context of nuclear medicine. This ligand is known for its unusual reverse size selectivity, the preference for binding large over small metal ions. The radiolabeling properties of macropa with large radiometals
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