ArticlePrenatal diagnosis2022
Prenatally diagnosed isolated perimembranous ventricular septal defect: Genetic and clinical implications.
Article in Prenatal diagnosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Detection of fetal structural abnormalities at 20 and 30 weeks: a retrospective study of prenatal ultrasound screening.Journal of medical ultrasonics (2001) · 2026Article
- The Pre-Twin Screen Consortium proposal for fetal structural anomalies evaluation across all three trimesters in twin pregnancies.Archives of gynecology and obstetrics · 2025Article
- Maternal Risk Factors, Patterns, and Outcomes of Antenatal Congenital Anomalies: A Hospital-Based Study.Diagnostics (Basel, Switzerland) · 2025Article
- Assessment of Fetal Cardiac Geometry and Systolic Function in Fetuses With Ventricular Septal Defect During the Second Trimester Using Fetal Heart Quantification Technology.Prenatal diagnosis · 2025Article
- Routine 36-week scan: diagnosis of fetal abnormalities.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Early Clinical Outcomes in Infants with Prenatally Diagnosed Perimembranous and Muscular Ventricular Septal Defects (VSDs).Pediatric cardiology · 2024Article
- Prenatal finding of isolated ventricular septal defect: genetic association, outcomes and counseling.Frontiers in genetics · 2024Review
- Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow-up six months after birth.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Prenatally diagnosed isolated perimembranous ventricular septal defect: Genetic and clinical implications.Prenatal diagnosis · 2022Article
- Should prenatal chromosomal microarray analysis be offered for isolated ventricular septal defect? A single-center retrospective study from China.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the incidence of chromosomal aberrations and the clinical outcomes following the prenatal diagnosis of isolated perimembranous ventricular septal defect (pVSD).
methodsThis retrospective study was composed of a cohort of pregnant women whose fetuses were diagnosed with isolated pVSD. Complete examinations of the fetal heart were performed, as well as a postnatal validation echocardiography follow-up at 1 year of age. The collected data included: spontaneous closure of the pVSD, need for intervention, chromosomal aberrations and postnatal outcome.
resultsFifty-five pregnant women were included in the study. 34/55 (61.8%) of the fetuses underwent prenatal genetic workup which revealed no abnormal results. No dysmorphic features or abnormal neurological findings were detected postnatally in those who declined a prenatal genetic workup during the follow-up period of 2 years. In 25/55 of the cases (45.4%), the ventricular septal defects (VSD) closed spontaneously in utero, whereas in 17 cases of this group (30.9%) the VSD closed during the first year of life. None of the large 3 VSDs cases (>3 mm), closed spontaneously.
conclusionPrenatally isolated perimembranous VSD has a favorable clinical outcome when classified as small-to-moderate size, children in our cohort born with such findings had no macroscopic chromosomal abnormalities.
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