Evidence map›Paper›PMID 35230648›Full record

ArticleJournal of gastrointestinal cancer2023

PEG-Asparaginase Single-Agent Rescue in an Advanced Case of Monomorphic Epitheliotropic Intestinal T Cell Lymphoma.

Emiliano Barbieri, Stefano Pozzi, Roberta Gelmini, Luca Roncati, Monica Maccaferri, Leonardo Potenza, Roberto Marasca, Mario Luppi, Giovanna Leonardi

Open access · greenAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Emiliano BarbieriHematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria Di Modena, University of Modena and Reggio Emilia, Modena, Italy. 163235@studenti.unimore.it.ORCID http://orcid.org/0000-0003-3148-6608
Stefano PozziHematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria Di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Roberta GelminiSurgery Unit, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria Di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Luca RoncatiInstitute of Pathology, University of Modena and Reggio Emilia, Modena, Italy.
Monica MaccaferriHematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria Di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Leonardo PotenzaHematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria Di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Roberto MarascaHematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria Di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Mario Luppi *Hematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria Di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Giovanna Leonardi *Hematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria Di Modena, University of Modena and Reggio Emilia, Modena, Italy.
University of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMEITL is a very rare and highly aggressive peripheral T cell lymphoma with poor prognosis and for which there is no standard treatment. Treatment options for patients patients with relapsed/refractory disease are scarce and the choice of an appropriate rescue still represents an unmet need.

methodsHere, we report the case of a 65-year-old woman affected by MEITL, progressing after initial treatment with an anthracycline-based chemotherapy and surgery, who received single-agent PEG-asparaginase salvage therapy at our institution.

resultsPEG-asparaginase single-agent rescue proved to be rapidly effective in controlling the disease and its associated paraneoplastic features. Nevertheless, toxicity was high and the patient died due to a treatment-related complication.

conclusionThe case we described brings new evidences on the effectiveness of PEG-asparaginase therapy in MEITL patients. Whether PEG-asparaginase should be included in the treatment course of MEITL patients could be the subject of future studies.

Indexed as

Enteropathy-Associated T-Cell LymphomaAgedAsparaginaseFemaleHumansPolyethylene GlycolsAsparaginasepegaspargasePolyethylene GlycolsExtranodal lymphomasGastrointestinal lymphomasMonomorphic epitheliotropic intestinal T cell lymphomaPEG-asparaginaseT cell lymphomas

Identifiers

PMID35230648
OpenAlexW4220727650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.