Evidence map›Paper›PMID 35230543›Full record

ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2023

Characterization of vitamin D deficiency and use of a standardized supplementation protocol in orthopaedic trauma patients.

Andrew S Gudeman, Serena A Dine, Todd A Walroth, Allison N Boyd, Evan D Zahn, Joseph E Jacobson, Brian H Mullis

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Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew S GudemanDepartment of Orthopaedic Surgery, Indiana University School of Medicine, 1801 N Senate Blvd, Ste 535, Indianapolis, IN, 46202, USA.
Serena A DineDepartment of Pharmacy, Eskenazi Health, Indianapolis, IN, USA.
Todd A WalrothDepartment of Pharmacy, Eskenazi Health, Indianapolis, IN, USA.
Allison N BoydDepartment of Pharmacy, Eskenazi Health, Indianapolis, IN, USA.
Evan D ZahnDepartment of Pharmacy, Yale-New Haven Health Hospital, New Haven, CT, USA.
Joseph E JacobsonDepartment of Orthopaedic Surgery, Indiana University School of Medicine, 1801 N Senate Blvd, Ste 535, Indianapolis, IN, 46202, USA.
Brian H MullisDepartment of Orthopaedic Surgery, Indiana University School of Medicine, 1801 N Senate Blvd, Ste 535, Indianapolis, IN, 46202, USA. bmullis@iupui.edu.ORCID http://orcid.org/0000-0002-5750-2533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objectives of this study were to assess the incidence of vitamin D deficiency in orthopaedic trauma patients, evaluate the safety and efficacy of a vitamin D supplementation protocol, and investigate the utility of vitamin D supplementation in reducing nonunions.

methodsThree hundred seventy patients with operative tibia and/or fibula fractures were retrospectively reviewed. Both overall and matched cohorts were analysed.

resultsNinety-eight per cent (n = 210) were found to have vitamin D insufficiency (serum 25(OH)D level < 30 ng/ml). There were no cases of vitamin D toxicity following vitamin D replacement. Median follow-up vitamin D level was 22.7 ng/mL. No statistical difference between union rates was found between either the two consecutive cohorts or matched cohorts.

conclusionThis vitamin D replacement protocol was a safe treatment for hypovitaminosis D, but post hoc analysis shows there would need to be over 1200 matched patients to achieve adequate power.

Indexed as

Fractures, BoneOrthopedicsVitamin D DeficiencyDietary SupplementsHumansRetrospective StudiesVitamin DVitaminsVitamin DVitaminsFractureNonunionReplacementTraumaVitamin D

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.