ArticleEuropean radiology2022
Coronary calcium scores on dual-source photon-counting computed tomography: an adapted Agatston methodology aimed at radiation dose reduction.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 24 citations in OpenAlex.
- Unconventional auricular reconstruction using controlled scaffold buckling and chondrogenic cocktail containing muscle-derived cells.Bioactive materials · 2026Article
- Coronary artery calcium scoring: expanding the new standard by photon-counting detector CT Part II: Impact of virtual monoenergetic image reconstructions with adjusted calcium scoring thresholds.European radiology · 2026Article
- Dietary index for gut microbiota score is inversely associated with carotid calcified plaque score in ischemic stroke patients.Frontiers in nutrition · 2026Article
- Reduction of radiation exposure and preserved image quality using photon-counting detector cardiac computed tomography without electrocardiographic gating in children with congenital heart disease.European radiology · 2026Article
- Applicability of Effective Atomic Number (Zeff) Image Analysis of Coronary Plaques Measured With Photon- Counting Computed Tomography.Investigative radiology · 2025Article
- Spectral Imaging Techniques in Heart Disease Assessment Using Photon-Counting Detector Computed Tomography.Echocardiography (Mount Kisco, N.Y.) · 2025Review
- The Association between Lipoprotein(a) and Coronary Artery Calcification in Elderly Patients with Diabetes: A Cross-Sectional Study.Reviews in cardiovascular medicine · 2025Article
- Effect of temporal resolution on calcium scoring: insights from photon-counting detector CT.The international journal of cardiovascular imaging · 2025Article
- Quantification accuracy in photon-counting detector CT for coronary artery calcium score: a pilot study.The international journal of cardiovascular imaging · 2024Article
- Technical principles, benefits, challenges, and applications of photon counting computed tomography in coronary imaging: a narrative review.Cardiovascular diagnosis and therapy · 2024Review
- Spectral Photon-Counting Computed Tomography: Technical Principles and Applications in the Assessment of Cardiovascular Diseases.Journal of clinical medicine · 2024Review
- Cardiovascular Applications of Photon-Counting CT Technology: A Revolutionary New Diagnostic Step.Journal of cardiovascular development and disease · 2023Review
- Virtual monochromatic images for coronary artery imaging with a spectral photon-counting CT in comparison to dual-layer CT systems: a phantom and a preliminary human study.European radiology · 2023Article
- Radiation dose optimization for photon-counting CT coronary artery calcium scoring for different patient sizes: a dynamic phantom study.European radiology · 2023Article
- Radiation dose optimization for photon-counting CT coronary artery calcium scoring for different patient sizes: a dynamic phantom study.European radiology · 2023Article
- Article
- Cardiac Virtual Noncontrast Images for Calcium Quantification with Photon-counting Detector CT.Radiology. Cardiothoracic imaging · 2023Article
- Radiation Dose Reduction for Coronary Artery Calcium Scoring Using a Virtual Noniodine Algorithm on Photon-Counting Detector Computed-Tomography Phantom Data.Diagnostics (Basel, Switzerland) · 2023Article
- Photon-counting CT of elbow joint fractures: image quality in a simulated post-trauma setting with off-center positioning.European radiology experimental · 2023Article
- Photon-Counting Computed Tomography (PCCT): Technical Background and Cardio-Vascular Applications.Diagnostics (Basel, Switzerland) · 2023Review
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to determine mono-energetic (monoE) level-specific photon-counting CT (PCCT) Agatston thresholds, to yield monoE level independent Agatston scores validated with a dynamic cardiac phantom. Also, we examined the potential of dose reduction for PCCT coronary artery calcium (CAC) studies, when reconstructed at low monoE levels.
methodsTheoretical CAC monoE thresholds were calculated with data from the National Institute of Standards and Technology (NIST) database. Artificial CAC with three densities were moved in an anthropomorphic thorax phantom at 0 and 60-75 bpm, and scanned at full and 50% dose on a first-generation dual-source PCCT. For all densities, Agatston scores and maximum CT numbers were determined. Agatston scores were compared with the reference at full dose and 70 keV monoE level; deviations (95% confidence interval) < 10% were deemed to be clinically not-relevant.
resultsAveraged over all monoE levels, measured CT numbers deviated from theoretical CT numbers by 6%, 13%, and - 4% for low-, medium-, and high-density CAC, respectively. At 50% reduced dose and 60-75 bpm, Agatston score deviations were non-relevant for 60 to 100 keV and 60 to 120 keV for medium- and high-density CAC, respectively.
conclusionMonoE level-specific Agatston score thresholds resulted in similar scores as in standard reconstructions at 70 keV. PCCT allows for a potential dose reduction of 50% for CAC scoring using low monoE reconstructions for medium- and high-density CAC. KEY POINTS: • Mono-energy level-specific Agatston thresholds allow for reproducible coronary artery calcium quantification on mono-energetic images. • Increased calcium contrast-to-noise ratio at reduced mono-energy levels allows for coronary artery calcium quantification at 50% reduced radiation dose for medium- and high-density calcifications.
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