Evidence map›Paper›PMID 35230136›Full record

ArticleThe British journal of radiology2022

A reproducible dynamic phantom for sequence testing in hyperpolarised

Rafat Chowdhury, Marianthi-Vasiliki Papoutsaki, Christoph A Müller, Lorna Smith, Fiona Gong, Max Bullock, Harriet Rogers, Manju Mathew, Tom Syer, Saurabh Singh and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A Static Phantom for Harmonization of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  2. Article
  3. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rafat ChowdhuryCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Marianthi-Vasiliki PapoutsakiCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Christoph A MüllerDepartment of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Lorna SmithGold Standard Phantoms Limited, London, UK.
Fiona GongCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Max BullockCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Harriet RogersCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Manju MathewCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Tom SyerCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Saurabh SinghCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Adam RetterCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Lucy CaseltonCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Jung RyuCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Aaron Oliver-TaylorGold Standard Phantoms Limited, London, UK.
Xavier GolayGold Standard Phantoms Limited, London, UK.
Alan BainbridgeDepartment of Medical Physics and Biomedical Engineering, University College London Hospitals, London, UK.
David G GadianUCL Great Ormond Street Institute of Child Health, London, UK.
Shonit PunwaniCentre for Medical Imaging, Division of Medicine, University College London, London, UK.

Funding

Cancer Research UK 26854
6 · The paper itself

Abstract

objectiveTo develop a phantom system which can be integrated with an automated injection system, eliminating the experimental variability that arises with manual injection; for the purposes of pulse sequence testing and metric derivation in hyperpolarised

methodsThe custom dynamic phantom was machined from Ultem and filled with a nicotinamide adenine dinucleotide and lactate dehydrogenase mixture dissolved in phosphate buffered saline. Hyperpolarised [1-

resultsThe phantom showed low coefficient of variation for the lactate to pyruvate peak signal heights (11.6%) and dynamic area-under curve ratios (11.0%). The variance for the lactate dehydrogenase enzyme rate constant (kP) was also seen to be low at 15.6%.

conclusionThe dynamic phantom demonstrates high reproducibility for quantification of ADVANCES IN KNOWLEDGE: The dynamic phantom developed during the course of this study will be a useful tool in testing new pulse sequences and standardisation in future hyperpolarised work.

Indexed as

Magnetic Resonance ImagingPyruvic AcidCarbon IsotopesHumansLactate DehydrogenasesLactic AcidMagnetic Resonance SpectroscopyReproducibility of ResultsCarbon IsotopesLactate DehydrogenasesLactic AcidPyruvic Acid

Identifiers

PMID35230136
PMCPMC10996405

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.