Evidence map›Paper›PMID 35230130›Full record

ArticleMicrobiology spectrum2022

Multicenter Genomic Analysis of Carbapenem-Resistant Klebsiella pneumoniae from Bacteremia in China.

Astrid V Cienfuegos-Gallet, Ying Zhou, Wenxiu Ai, Barry N Kreiswirth, Fangyou Yu, Liang Chen

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Expanding Threat of Carbapenemase-ProducingbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Dissemination ofMicrobiology spectrum · 2025
    Article
  8. Emerging carbapenem-resistantMicrobiology spectrum · 2025
    Article
  9. Multispecies emergence of dualAntimicrobial agents and chemotherapy · 2025
    Article
  10. Molecular epidemiology of carbapenem-resistantFrontiers in microbiology · 2025
    Article
  11. Carbapenem-resistantFrontiers in cellular and infection microbiology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Microbiology spectrum · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Astrid V Cienfuegos-GalletCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-3407-6463
Ying ZhouDepartment of Clinical Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Wenxiu AiDepartment of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Barry N KreiswirthCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-0243-131X
Fangyou YuDepartment of Clinical Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.ORCID 0000-0003-4924-2484
Liang ChenCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0001-5845-2235
Hackensack Meridian Health · USTongji University · CNUniversidad de Antioquia · COWenzhou Medical University · CN

Funding

The molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2M
NIAID NIH HHS R01 AI090155
6 · The paper itself

Abstract

Klebsiella pneumoniae is one of the most common Gram-negative bacilli isolated from bloodstream infections worldwide, and recently an increased rate of carbapenem resistance has been reported in this pathogen. This study aims to describe the genomic characteristics of carbapenem-resistant K. pneumoniae (CRKP) isolated from patients with bacteremia in China. We analyzed 147 isolates from patients with bacteremia attended in 12 referral hospitals in China between April 2015 and November 2018. We conducted a phenotypic susceptibility evaluation and whole genome sequence analysis to characterize antimicrobial resistance profile, virulence genes, and dominant clones among CRKP. ST11 accounted for most infections (

Indexed as

BacteremiaCarbapenem-Resistant EnterobacteriaceaeKlebsiella InfectionsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsGenomicsHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsbacteremiacarbapenem-resistanceintra-hospital transmissionKlebsiella pneumoniae

Identifiers

PMID35230130
PMCPMC9045280
OpenAlexW4214749174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.