ArticleAnimal models and experimental medicine2022
A comprehensive neuromonitoring approach in a large animal model of cardiac arrest.
Article in Animal models and experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Pre-Clinical Models of Traumatic Brain Injury-A Narrative Review Towards "Animal Neuro-ICUs".Biomedicines · 2026Review
- Wolf Creek XVIII Part 8: Wolf Creek Innovator in Cardiac Arrest and Resuscitation Science Award.Resuscitation plus · 2026Article
- Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation.Intensive care medicine experimental · 2025Article
- Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma.Cells · 2024Article
- Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest.Critical care (London, England) · 2024Article
- Extracorporeal cardiopulmonary resuscitation: a comparison of two experimental approaches and systematic review of experimental models.Intensive care medicine experimental · 2024Article
- Hypertonic sodium lactate infusion reduces vasopressor requirements and biomarkers of brain and cardiac injury after experimental cardiac arrest.Critical care (London, England) · 2023Article
- A comprehensive neuromonitoring approach in a large animal model of cardiac arrest.Animal models and experimental medicine · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnoxic brain injuries represent the main determinant of poor outcome after cardiac arrest (CA). Large animal models have been described to investigate new treatments during CA and post-resuscitation phase, but a detailed model that includes extensive neuromonitoring is lacking.
methodBefore an electrically-induced 10-minute CA and resuscitation, 46 adult pigs underwent neurosurgery for placement of a multifunctional probe (intracranial pressure or ICP, tissue oxygen tension or PbtO
result42 animals underwent the CA procedure and 41 achieved the return of spontaneous circulation (ROSC). In 4 cases (8.6%) an adverse event took place during preparation, but only in two cases (4.3%) this was related to the neurosurgery. In 6 animals (13.3%) the minor complications that occurred resolved after probe repositioning.
conclusionHerein we provide a detailed comprehensive neuromonitoring approach in a large animal model of CA that might help future research.
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