Evidence map›Paper›PMID 35229947›Full record

ArticleAddiction biology2022

From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self-administration in male rats.

Leandro Ruiz-Leyva, Ana Vázquez-Ágredos, Ana M Jiménez-García, Olga López-Guarnido, Antonio Pla, Ricardo Marcos Pautassi, Ignacio Morón Henche, Cruz Miguel Cendán

Open access · greenAbstract read
In one paragraph

Article in Addiction biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. [Establishment and evaluation of rat and mouse models with addictive behaviors].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Leandro Ruiz-LeyvaDepartment of Pharmacology, Institute of Neuroscience, Biomedical Research Center (CIBM) Faculty of Medicine, University of Granada, Granada, Spain.ORCID 0000-0001-8865-4903
Ana Vázquez-ÁgredosInstituto de Investigación Biosanitaria (IBS), Granada, Spain.ORCID 0000-0002-4953-3161
Ana M Jiménez-GarcíaDepartment of Psychology, Faculty of Life Sciences and Nature, University of Nebrija, Hoyo de Manzanares, Spain.ORCID 0000-0001-6400-3436
Olga López-GuarnidoDepartment of Legal Medicine and Toxicology, Faculty of Medicine, University of Granada, Spain.ORCID 0000-0001-6229-9122
Antonio PlaDepartment of Legal Medicine and Toxicology, Faculty of Medicine, University of Granada, Spain.
Ricardo Marcos PautassiInstituto de Investigación Médica M. y M. Ferreyra, INIMEC-CONICET, Universidad Nacional de Córdoba (INIMEC-CONICET-UNC) y Facultad de Psicología, UNC, Córdoba, Argentina.ORCID 0000-0003-1876-2321
Ignacio Morón HencheDepartment of Psychobiology and Centre of Investigation of Mind, Brain, and Behavior (CIMCYC), Faculty of Psychology, University of Granada, Granada, Spain.ORCID 0000-0002-1387-5602
Cruz Miguel CendánDepartment of Pharmacology, Institute of Neuroscience, Biomedical Research Center (CIBM) Faculty of Medicine, University of Granada, Granada, Spain.ORCID 0000-0001-5431-4513
Universidad de Granada · ESConsejo Nacional de Investigaciones Científicas y Técnicas · ARInstituto de Investigación Biosanitaria de Granada · ESUniversidad Nebrija · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animal models of alcohol (ethanol) self-administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self-administration co-occurs with other addictive behaviours. The present study aims to validate a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Over 10 sessions, Wistar rats were exposed to binge or control eating (i.e., the ingestion of 11.66 and 0.97 kcal/3 min, respectively, derived from a highly palatable food), immediately followed by two-bottle choice intake tests (2%, 6%, 10% or 14% w/w ethanol vs. water). Rats exposed to binge eating drank significantly more 6% or 10% (w/w) ethanol than control peers, reaching up to 6.3 g

Indexed as

Binge DrinkingBinge-Eating DisorderAlcohol DrinkingAnimalsEthanolMaleRatsRats, WistarSelf AdministrationEthanolbinge drinkingbinge eatingethanolnaltrexoneself-administration

Identifiers

PMID35229947
PMCPMC9285499
OpenAlexW4213008406

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.