Evidence map›Paper›PMID 35229942›Full record

ArticleAddiction biology2022

The serotonin 2A receptor agonist TCB-2 attenuates heavy alcohol drinking and alcohol-induced midbrain inhibitory plasticity.

Blake A Kimmey, Ruthie E Wittenberg, Alexandra Croicu, Nikita Shadani, Alexey Ostroumov, John A Dani

Open access · greenAbstract read
In one paragraph

Article in Addiction biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024
    Article
  6. Frontiers in psychiatry · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Blake A KimmeyDepartment of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-6559-8005
Ruthie E WittenbergDepartment of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alexandra CroicuDepartment of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nikita ShadaniDepartment of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alexey OstroumovDepartment of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-0362-3708
John A DaniDepartment of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · US

Funding

STRUCTURE/FUNCTION OF EXCITATORY SYNAPTIC CHANNELSR01NS021229 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DANI, JOHN A. · 1987 to 2021
$5.3M
Altered Midbrain GABAergic Circuitry Drives Greater Cocaine Self-administrationR37DA053296 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI John A. Dani · 2021 to 2026
$3.2M
Adolescent Exposure to Stress or Nicotine Increases Rodent Alcohol Self-AdministrationR01AA026267 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI DANI, JOHN A. · 2019 to 2023
$2.4M
CHOLINERGIC INFLUENCES NEURONAL CIRCUIT EXCITABILITYR37NS021229 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DANI, JOHN A. · 2000 to 2006
$2.1M
The Impact of Stress-induced KCC2 Downregulation on Mesolimbic Dopamine Signaling and Reward ProcessingR01MH125996 · NIMH · GEORGETOWN UNIVERSITY · PI Alexey Ostroumov · 2022 to 2026
$1.9M
Dysregulation of midbrain GABAergic circuitry contributes to the motivational properties of cocaineK01DA048134 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI OSTROUMOV, ALEXEY · 2019 to 2023
$797k
Adolescent nicotine-induced enhancement of adult morphine reward: mediation by midbrain inhibitory circuitsF31DA053111 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WITTENBERG, RUTHIE · 2021 to 2022
$80k
Serotonin 2A receptor activation attenuates alcohol consumption following stress and protracted alcohol exposure via upregulation of the chloride transporter KCC2 in VTA GABA neuronsF31AA026766 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI KIMMEY, BLAKE · 2018 to 2019
$45k
NIAAA NIH HHS F31 AA026766NIAAA NIH HHS R01 AA026267NIDA NIH HHS F31 DA053111NIDA NIH HHS K01 DA048134NIDA NIH HHS R01 DA053296NIDA NIH HHS R37 DA053296NIMH NIH HHS R01 MH125996NINDS NIH HHS R01 NS021229NINDS NIH HHS R37 NS021229
6 · The paper itself

Abstract

Disruption of neuronal chloride ion (Cl

Indexed as

Receptor, Serotonin, 5-HT2AVentral Tegmental AreaAlcohol DrinkingAnimalsEthanolGABAergic NeuronsMaleMiceEthanolReceptor, Serotonin, 5-HT2AaddictionalcoholCl− homeostasisGABAreward circuitryTCB-2VTA

Identifiers

PMID35229942
PMCPMC8896307
OpenAlexW4211232046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.