Evidence map›Paper›PMID 35229888›Full record

ArticleThe Journal of physiology2022

Ca

Bernard T Drumm, Karen I Hannigan, Ji Yeon Lee, Benjamin E Rembetski, Salah A Baker, Sang Don Koh, Caroline A Cobine, Kenton M Sanders

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Orai storeoperated CaChannels (Austin, Tex.) · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  10. Article
  11. Review
  12. CaPhysiological reviews · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. LEtS set the tone.The Journal of physiology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Bernard T DrummDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.ORCID 0000-0002-4762-844X
Karen I HanniganDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Ji Yeon LeeDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Benjamin E RembetskiDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Salah A BakerDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Sang Don KohDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Caroline A CobineDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.ORCID 0000-0002-2871-3825
Kenton M SandersDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.ORCID 0000-0002-4196-1583
University of Nevada, Reno · US

Funding

Single Cell Molecular ExpressionP30GM110767 · NIGMS · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2014 to 2018
$5.4M
Control of motility in the internal anal sphincterR01DK078736 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KEEF, KATHLEEN D · 2010 to 2019
$3.4M
Role of interstitial cells of Cajal in patterned colonic motor activityR01DK120759 · NIDDK · UNIVERSITY OF NEVADA RENO · PI Sal Baker, KENTON M SANDERS · 2019 to 2026
$3.4M
Control of motility in the lower esophageal sphincterR01DK129528 · NIDDK · UNIVERSITY OF NEVADA RENO · PI COBINE, CAROLINE ANN · 2021 to 2025
$2.1M
NIDDK NIH HHS DK078736NIDDK NIH HHS DK129528NIDDK NIH HHS R01 DK078736NIDDK NIH HHS R01 DK120759NIDDK NIH HHS R01 DK129528NIGMS NIH HHS P30 GM110767NIGMS NIH HHS P30-GM110767
6 · The paper itself

Abstract

The lower oesophageal sphincter (LES) generates tone and prevents reflux of gastric contents. LES smooth muscle cells (SMCs) are relatively depolarised, facilitating activation of Ca

Indexed as

Interstitial Cells of CajalAnimalsCaffeineCalcium SignalingEsophageal Sphincter, LowerHaplorhiniMiceMuscle, SmoothNifedipineCaffeineNifedipineanoctamin-1 channelsCa2+ handling mechanismsL-type Ca2+ channelsoesophageal refluxSIP syncytiumsmooth muscle cellsswallowing reflex

Identifiers

PMID35229888
PMCPMC9167266
OpenAlexW4214617076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.