SynthesisInternational journal of epidemiology2022
Association between body mass index and oesophageal cancer mortality: a pooled analysis of prospective cohort studies with >800 000 individuals in the Asia Cohort Consortium.
Synthesis in International journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Prognostic impact of low BMI on outcomes following definitive radiotherapy for esophageal squamous cell carcinoma.Frontiers in nutrition · 2026Article
- Oral microbes and gastrointestinal cancers: new strategies and insights.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- Comparison of Population Attributable Fractions of Cancer Incidence and Mortality Linked to Excess Body Weight in Korea from 2015 to 2030.Endocrinology and metabolism (Seoul, Korea) · 2024Article
- Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia.JAMA network open · 2024Article
- Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990-2019.Thoracic cancer · 2024Observational
- Trends in the burden of most common obesity-related cancers in 16 Southern Africa development community countries, 1990-2019. Findings from the global burden of disease study.Obesity science & practice · 2024Article
- The relationship between lipoproteins and the risk of esophageal cancer: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Complete genome sequence and anti-obesity potential ofFrontiers in microbiology · 2024Article
- Body mass index and esophageal and gastric cancer: A pooled analysis of 10 population-based cohort studies in Japan.Cancer science · 2023Article
- Effect of Caffeine Consumption on Cardiovascular Disease: An Updated Review.Pharmaceutical medicine · 2023Review
- High Body Mass Index Is Associated with an Increased Risk of the Onset and Severity of Ossification of Spinal Ligaments.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
43 authors at 20 institutions in 8 countries.
Funding
Abstract
backgroundThe association between body mass index (BMI) and oesophageal cancer (OC) has been consistently negative among Asians, whereas different associations based on histological OC subtypes have been observed in Europeans and North Americans. We examined the association between BMI and OC mortality in the Asia Cohort Consortium.
methodsWe performed a pooled analysis to evaluate the association between BMI and OC mortality among 842 630 Asians from 18 cohort studies. Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs.
resultsA wide J-shaped association between BMI and overall OC mortality was observed. The OC mortality risk was increased for underweight (BMI <18.5 kg/m2: HR = 2.20, 95% CI 1.80-2.70) and extreme obesity (BMI ≥35 kg/m2: HR = 4.38, 95% CI 2.25-8.52) relative to the reference BMI (23-25 kg/m2). This association pattern was confirmed by several alternative analyses based on OC incidence and meta-analysis. A similar wide J-shaped association was observed in oesophageal squamous cell carcinoma (OSCC). Smoking and alcohol synergistically increased the OC mortality risk in underweight participants (HR = 6.96, 95% CI 4.54-10.67) relative to that in reference BMI participants not exposed to smoking and alcohol.
conclusionExtreme obesity and being underweight were associated with an OC mortality risk among Asians. OC mortality and BMI formed a wide J-shaped association mirrored by OSCC mortality. Although the effect of BMI on OSCC and oesophageal adenocarcinoma mortality can be different in Asians, further research based on a large case-control study is recommended.
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