ArticleeLife2022
A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation.
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In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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0cells of the map it votes in
24citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
What it found
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Who cites it
24 citing papers in PubMed, 26 citations in OpenAlex.
- Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review).International journal of molecular medicine · 2026Review
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Polycystin-1 and Cardiac Remodeling: From Mechanotransduction to Clinical Consequences.Circulation research · 2026Review
- Cardiac mechanotransduction from development to disease.APL bioengineering · 2026Review
- The primary cilium-autophagy axis in vascular homeostasis and cardiovascular disease: mechanistic crosstalk and evidence boundaries.Frontiers in cardiovascular medicine · 2026Review
- Polycystin-1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1-Dependent Microfilament Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Endothelial CYB5R3 couples store-operated calcium entry to TRPV2 activation and vascular fitness.bioRxiv : the preprint server for biology · 2025Article
- Article
- Autosomal Dominant Polycystic Kidney Disease: From Pathogenesis to Organoid Disease Models.Biomedicines · 2025Review
- Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Role in Cystogenesis and Novel Therapeutic Approaches.Biomedicines · 2025Review
- Transient Receptor Potential Channels in Vascular Mechanotransduction.American journal of hypertension · 2025Review
- Cardiac Localized Polycystin-2 in the Natriuretic Peptide Signaling Pathway and Hypertension.Journal of the American Society of Nephrology : JASN · 2025Article
- The mutual interaction of TRPC5 channel with polycystin proteins.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025Article
- Review
- Mechanical protein polycystin-1 directly regulates osteoclastogenesis and bone resorption.Science bulletin · 2024Article
- Vascular polycystin proteins in health and disease.Microcirculation (New York, N.Y. : 1994) · 2024Review
- Cardiovascular perspectives of the TRP channel polycystin 2.The Journal of physiology · 2024Article
- Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure.Science signaling · 2023Article
- Cardiovascular Manifestations and Management in ADPKD.Kidney international reports · 2023Review
- Diabetic Endothelial Cell Glycogen Synthase Kinase 3β Activation Induces VCAM1 Ectodomain Shedding.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Charles E MacKayDepartment of Physiology, University of Tennessee Health Science Center, Memphis, United States.ORCID 0000-0002-2875-0677
Miranda FloenDepartment of Physiology, University of Tennessee Health Science Center, Memphis, United States.
M Dennis LeoDepartment of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Raquibul HasanDepartment of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Tessa A C GarrudDepartment of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Carlos Fernández-PeñaDepartment of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Purnima SinghDepartment of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Kafait U MalikDepartment of Physiology, University of Tennessee Health Science Center, Memphis, United States.
Jonathan H JaggarDepartment of Physiology, University of Tennessee Health Science Center, Memphis, United States.ORCID 0000-0003-1505-3335
University of Tennessee Health Science Center · US
Funding
Angiotensins, Prostaglandins and Adrenergic InteractionsR01HL019134 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KAFAIT U MALIK · 1985 to 2026
$14.7MSK3 channel trafficking in endothelial cellsR01HL158846 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2021 to 2024
$2.5MPKD proteins in endothelial cellsR01HL155180 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2021 to 2024
$2.4MEndothelial cell potassium channelsR01HL137745 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$2.0MChloride channels in diabetic vascular diseaseR01HL149662 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LEO, M. DENNIS MARCUS · 2020 to 2024
$1.9MBlood pressure regulation by smooth muscle cell ion channelsR01HL133256 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$1.5MMedical Research Council MC_EX_MR/N50192X/1Medical Research Council MR/M024962/1NHLBI NIH HHS R01 HL019134NHLBI NIH HHS R01 HL133256NHLBI NIH HHS R01 HL137745NHLBI NIH HHS R01 HL149662NHLBI NIH HHS R01 HL155180NHLBI NIH HHS R01 HL158846
Abstract
Polycystin-1 (PC-1, PKD1), a receptor-like protein expressed by the
Indexed as
VasodilationAnimalsCell MembraneEndothelial CellsMiceMice, KnockoutPolycystic Kidney DiseasesTRPP Cation ChannelsTRPP Cation Channelsblood pressureendothelial cellflowmolecular biophysicsmouseneurosciencepolycystin-1polycystin-2structural biologyvasodilation
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.