Evidence map›Paper›PMID 35229615›Full record

Observational studyJournal of the American Heart Association2022

Impact of the COVID-19 Pandemic on Patients Without COVID-19 With Acute Myocardial Infarction and Heart Failure.

Daniel K Fox, R J Waken, Daniel Y Johnson, Gmerice Hammond, Jonathan Yu, Erika Fanous, Thomas M Maddox, Karen E Joynt Maddox

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Daniel K FoxDepartment of Medicine Cardiovascular DivisionWashington University School of Medicine St. Louis MO.
R J WakenDepartment of Medicine Cardiovascular DivisionWashington University School of Medicine St. Louis MO.ORCID 0000-0001-6678-7764
Daniel Y JohnsonDepartment of Medicine Cardiovascular DivisionWashington University School of Medicine St. Louis MO.
Gmerice HammondDepartment of Medicine Cardiovascular DivisionWashington University School of Medicine St. Louis MO.
Jonathan YuDepartment of Medicine Cardiovascular DivisionWashington University School of Medicine St. Louis MO.ORCID 0000-0003-3109-1016
Erika FanousDepartment of Medicine Cardiovascular DivisionWashington University School of Medicine St. Louis MO.
Thomas M MaddoxDepartment of Medicine Cardiovascular DivisionWashington University School of Medicine St. Louis MO.ORCID 0000-0003-1426-9433
Karen E Joynt MaddoxDepartment of Medicine Cardiovascular DivisionWashington University School of Medicine St. Louis MO.ORCID 0000-0003-3779-8653
Washington University in St. Louis · US

Funding

PRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6M
SHORT-TERM TRAINING STUDENTS IN HEALTH PROFESSIONAL SCHOT35HL007815 · NHLBI · WASHINGTON UNIVERSITY · PI CHUNG, KOONG-NAH · 1995 to 2020
$2.8M
Improving the Quality of Care Provided Through Bundled Payments for Patients with Alzheimer's Disease or Other Forms of Dementia or FrailtyR01AG060935 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI EPSTEIN, ARNOLD, JOYNT MADDOX, KAREN ELLEN · 2019 to 2021
$2.7M
Observation Stays and Readmissions for Older Adults: Implications for Medicare PoliciesR01AG063759 · NIA · UNIVERSITY OF WASHINGTON · PI SABBATINI, AMBER KATHLEEN · 2020 to 2023
$1.4M
The Effect of Patient Dementia on Outpatient Clinicians' Performance on Cost Outcomes Under Medicare Value-Based Payment.R21AG065526 · NIA · WASHINGTON UNIVERSITY · PI JOHNSTON, KENTON JAMES · 2020 to 2021
$308k
NHLBI NIH HHS T32 HL007081NHLBI NIH HHS T35 HL007815NIA NIH HHS R01 AG060935NIA NIH HHS R01 AG063759NIA NIH HHS R21 AG065526
6 · The paper itself

Abstract

Background Excess mortality from cardiovascular disease during the COVID-19 pandemic has been reported. The mechanism is unclear but may include delay or deferral of care, or differential treatment during hospitalization because of strains on hospital capacity. Methods and Results We used emergency department and inpatient data from a 12-hospital health system to examine changes in volume, patient age and comorbidities, treatment (right- and left-heart catheterization), and outcomes for patients with acute myocardial infarction (AMI) and heart failure (HF) during the COVID-19 pandemic compared with pre-COVID-19 (2018 and 2019), controlling for seasonal variation. We analyzed 27 427 emergency department visits or hospitalizations. Patient volume decreased during COVID-19 for both HF and AMI, but age, race, sex, and medical comorbidities were similar before and during COVID-19 for both groups. Acuity increased for AMI as measured by the proportion of patients with ST-segment elevation. There were no differences in right-heart catheterization for patients with HF or in left heart catheterization for patients with AMI. In-hospital mortality increased for AMI during COVID-19 (odds ratio [OR], 1.46; 95% CI, 1.21-1.76), particularly among the ST-segment-elevation myocardial infarction subgroup (OR, 2.57; 95% CI, 2.24-2.96), but was unchanged for HF (OR, 1.02; 95% CI, 0.89-1.16). Conclusions Cardiovascular volume decreased during COVID-19. Despite similar patient age and comorbidities and in-hospital treatments during COVID-19, mortality increased for patients with AMI but not patients with HF. Given that AMI is a time-sensitive condition, delay or deferral of care rather than changes in hospital care delivery may have led to worse cardiovascular outcomes during COVID-19.

Indexed as

Heart FailureMyocardial InfarctionCOVID-19HospitalizationHumansMissouriPandemicsST Elevation Myocardial Infarctionacute myocardial infarctionCOVID‐19heart failurespillover

Identifiers

PMID35229615
PMCPMC9075301
OpenAlexW4214643594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.