ArticleEMBO reports2022
RGI-GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity.
Article in EMBO reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Identification of candidate genes associated with major QTL controlling Vertcillium wilt resistance in cotton (Gossypium hirsutum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Plant Peptides on the Rise: From Historical Insight to Future Applications.Plant biotechnology journal · 2026Review
- Root-knot-nematode-derived mimics of RGF peptides hijack host signalling to orchestrate feeding site formation.Nature plants · 2026Article
- Processing and release of endogenous immunogenic peptide signals.The Plant journal : for cell and molecular biology · 2026Review
- Peptide signaling at the intersection of growth, nutrient sensing, and stress responses.The Plant journal : for cell and molecular biology · 2026Review
- Biorefining of Anaerobic Digestates for the Recovery of Biostimulants and Bioelicitors for Immune Priming and Plant Protection.Environmental science & technology · 2025Article
- Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants.Science advances · 2025Article
- Flagellin sensing, signaling, and immune responses in plants.Plant communications · 2025Review
- The Small Key to the Treasure Chest: Endogenous Plant Peptides Involved in Symbiotic Interactions.Plants (Basel, Switzerland) · 2025Review
- Peptide hormones in plants.Molecular horticulture · 2025Review
- CEP signaling coordinates plant immunity with nitrogen status.Nature communications · 2024Article
- The leucine-rich repeat receptor kinase QSK1 regulates PRR-RBOHD complexes targeted by the bacterial effector HopF2Pto.The Plant cell · 2024Article
- Pull the fuzes: Processing protein precursors to generate apoplastic danger signals for triggering plant immunity.Plant communications · 2024Review
- Sulfated peptides and their receptors: Key regulators of plant development and stress adaptation.Plant communications · 2024Review
- Unlocking Nature's Defense: Plant Pattern Recognition Receptors as Guardians Against Pathogenic Threats.Molecular plant-microbe interactions : MPMI · 2024Review
- Quantitative Measurement of Pattern-Triggered ROS Burst as an Early Immune Response in Tomato.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Subtilases: a major prospect to the genome editing in horticultural crops.Frontiers in plant science · 2024Review
- A Seedling Growth Inhibition Assay to Measure Phytocytokine Activity.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Sulfated peptides: key players in plant development, growth, and stress responses.Frontiers in plant science · 2024Review
- Subtilase-mediated biogenesis of the expanded family of SERINE RICH ENDOGENOUS PEPTIDES.Nature plants · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant immune responses must be tightly controlled for proper allocation of resources for growth and development. In plants, endogenous signaling peptides regulate developmental and growth-related processes. Recent research indicates that some of these peptides also have regulatory functions in the control of plant immune responses. This classifies these peptides as phytocytokines as they show analogies with metazoan cytokines. However, the mechanistic basis for phytocytokine-mediated regulation of plant immunity remains largely elusive. Here, we identify GOLVEN2 (GLV2) peptides as phytocytokines in Arabidopsis thaliana. GLV2 signaling enhances sensitivity of plants to elicitation with immunogenic bacterial elicitors and contributes to resistance against virulent bacterial pathogens. GLV2 is perceived by ROOT MERISTEM GROWTH FACTOR 1 INSENSITIVE (RGI) receptors. RGI mutants show reduced elicitor sensitivity and enhanced susceptibility to bacterial infection. RGI3 forms ligand-induced complexes with the pattern recognition receptor (PRR) FLAGELLIN SENSITIVE 2 (FLS2), suggesting that RGIs are part of PRR signaling platforms. GLV2-RGI signaling promotes PRR abundance independent of transcriptional regulation and controls plant immunity via a previously undescribed mechanism of phytocytokine activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.